In Silico Methods for Predicting Drug Toxicity

Häftad, Engelska, 2022

2 269 kr

Beställningsvara. Skickas inom 10-15 vardagar

Fri frakt för medlemmar vid köp för minst 249 kr.

Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological.

Produktinformation

Utgivningsdatum2022-03-01
Mått178 x 254 x 38 mm
Vikt1 286 g
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor680
Upplaga2
FörlagSpringer-Verlag New York Inc.
ISBN9781071619629

Tillhör följande kategorier

Systemvetenskap och AI inom Data och it
Farmakologi inom Medicin

QSAR Methods.- PBPK Modeling to Simulate the Fate of Compounds in Living Organisms.- Pharmacokinetic Tools and Applications.- In Silico Tools and Software to Predict ADMET of New Drug Candidates.- Development of In Silico Methods for Toxicity Prediction in Collaboration between Academia and the Pharmaceutical Industry.- Emerging Bioinformatics Methods and Resources in Drug Toxicology.- In Silico Prediction of Chemically-Induced Mutagenicity: A Weight of Evidence Approach Integrating Information from QSAR Models and Read-Across Predictions.- In Silico Methods for Chromosome Damage.- In Silico Methods for Carcinogenicity Assessment.- In Silico Models for Developmental Toxicity.- In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs.- In Silico Models for Predicting Acute Systemic Toxicity.- In Silico Models for Skin Sensitization and Irritation.- In Silico Models for Hepatotoxicity.- Machine Learning Models for Predicting Liver Toxicity.- Implementation of In Silico Toxicology Protocols in Leadscope.- Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity.- Using VEGAHUB within a Weight-of-Evidence Strategy.- MultiCASE Platform for In Silico Toxicology.- Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing.- The Use of In Silico Methods for the Regulatory Toxicological Assessment of Pharmaceutical Impurities.- Computational Modeling of Mixture Toxicity.- In Silico Methods for Ecological Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives.- Increasing the Value of Data within a Large Pharmaceutical Company through In Silico Models.