In Silico Methods for Predicting Drug Toxicity

Inbunden, Engelska, 2022

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Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological.

Produktinformation

Utgivningsdatum2022-02-22
Mått178 x 254 x 43 mm
Vikt1 484 g
FormatInbunden
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor680
Upplaga2
FörlagSpringer-Verlag New York Inc.
ISBN9781071619599

Tillhör följande kategorier

Systemvetenskap och AI inom Data och it
Farmakologi inom Medicin

QSAR Methods.- PBPK Modeling to Simulate the Fate of Compounds in Living Organisms.- Pharmacokinetic Tools and Applications.- In Silico Tools and Software to Predict ADMET of New Drug Candidates.- Development of In Silico Methods for Toxicity Prediction in Collaboration between Academia and the Pharmaceutical Industry.- Emerging Bioinformatics Methods and Resources in Drug Toxicology.- In Silico Prediction of Chemically-Induced Mutagenicity: A Weight of Evidence Approach Integrating Information from QSAR Models and Read-Across Predictions.- In Silico Methods for Chromosome Damage.- In Silico Methods for Carcinogenicity Assessment.- In Silico Models for Developmental Toxicity.- In Silico Models for Repeated-Dose Toxicity (RDT): Prediction of the No Observed Adverse Effect Level (NOAEL) and Lowest Observed Adverse Effect Level (LOAEL) for Drugs.- In Silico Models for Predicting Acute Systemic Toxicity.- In Silico Models for Skin Sensitization and Irritation.- In Silico Models for Hepatotoxicity.- Machine Learning Models for Predicting Liver Toxicity.- Implementation of In Silico Toxicology Protocols in Leadscope.- Use of Lhasa Limited Products for the In Silico Prediction of Drug Toxicity.- Using VEGAHUB within a Weight-of-Evidence Strategy.- MultiCASE Platform for In Silico Toxicology.- Adverse Outcome Pathways as Versatile Tools in Liver Toxicity Testing.- The Use of In Silico Methods for the Regulatory Toxicological Assessment of Pharmaceutical Impurities.- Computational Modeling of Mixture Toxicity.- In Silico Methods for Ecological Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives.- Increasing the Value of Data within a Large Pharmaceutical Company through In Silico Models.