Immunotoxicity Testing

Methods and Protocols

Häftad, Engelska, 2019

AvJamie C. DeWitt,Cheryl E. Rockwell,Christal C. Bowman

2 289 kr

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This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches.

Produktinformation

Utgivningsdatum2019-07-25
Mått178 x 254 x undefined mm
FormatHäftad
SpråkEngelska
SerieMethods in Molecular Biology
Antal sidor412
Upplaga2
FörlagHumana Press Inc.
ISBN9781493993222

Tillhör följande kategorier

Onkologi inom Medicin
Farmakologi inom Medicin

Immunotoxicology: A Brief History.- Clinical Immunotoxicology.- Investigative Immunotoxicology.- Developmental Immunotoxicity (DIT) Testing: Current Recommendations and the Future of DIT Testing.- Markers of Inflammation.- The Sheep Erythrocyte T-Dependent Antibody Response (TDAR).- Methylated-Bovine Serum Albumin (mBSA)-Induced Delayed-Type Hypersensitivity in Mice.- Use of the LLNA:BrdU-ELISA for Skin Sensitization Hazard Assessment.- Host Resistance Assays.- Enhanced Histopathology Evaluation of Lymphoid Organs.- Tumor Challenges in Immunotoxicity Testing.- Flow Cytometry for the Immunotoxicologist.- Evaluation of Cell-Mediated Immune Function Using the Cytotoxic T Lymphocyte Assay.- Evaluation of Cell Proliferation and Apoptosis in Immunotoxicity Testing.- Natural Killer (NK) Cell Assays in Immunotoxicity Testing.- Dendritic Cell Assays.- Evaluating Macrophages in Immunotoxicity Testing.- Evaluating Cytokines in Immunotoxicity Testing.- Functional Assays of Hematopoietic Stem Cellsin Toxicology Research.- CD4+ T Cell Differentiation and Activation.- Isolation and Identification of Innate Lymphoid Cells (ILCs) for Immunotoxicity Testing.- Evaluating Antigen-Specific IgE Using the Rat Basophil Leukemia Cell (RBL) Assay.- Challenges for Integrating Immunotoxicology into the 21st Century Toxicology Testing Paradigm.