EditorDr Shyamala Dakshinamurti is a neonatologist and biomedical researcher, Professor of Pediatrics and Physiology at the University of Manitoba, Canada, and member of the Biology of Breathing theme, Children’s Hospital Research Institute of Manitoba.Section EditorsDr Steven H. Abman is Professor of Pediatrics and Director of the Pediatric Heart Lung Center at the University of Colorado Anschutz School of Medicine and the Children’s Hospital Colorado, USA.Dr Po-Yin Cheung is a neonatologist of the Northern Alberta Neonatal Program of Alberta Health Services and Professor in the Departments of Pediatrics, Pharmacology and Surgery at the University of Alberta, Canada.Dr Satyan Lakshminrusimha is a neonatologist and the Dennis and Nancy Marks Chair and Professor of Pediatrics at the University of California at Davis, Sacramento, USA.Dr Patrick McNamara is a staff neonatologist and Director of the Division of Neonatology at the University of Iowa Stead Family Children’s Hospital and Professor of Pediatrics and Internal Medicine, University of Iowa, USA.Dr William K. Milsom is a comparative physiologist and Emeritus Professor of Zoology at the University of British Columbia, Canada.

• Table of Contents1. IntroductionPart 1: The Origins of Hypoxia Tolerance 2. The Human Fetus and Metabolic Adaptations to Hypoxia3. Hypoxia as a Neuroinflammatory Stimulus During Development4. Human Adaptations to High Altitude5. Fetal Llama Adaptation to Altitude in the Andean Altiplano6. Neonates of Burrowing and Hibernating Mammals: Metabolic and Respiratory Adaptations to Hypoxia7. Diving Response and Hypoxia in Deep Sea Mammals8. The Phylogeny and Ontogeny of Cardiorespiratory Coupling in Vertebrates and its Relevance to Non-Invasive Monitoring of the Human FetusPart 2: Fetal Hypoxia and Neonatal Transition9. Fetal and Neonatal Oxygen Environment10. Fetal Oxygenation During Maternal Hypoxic Illness11. Hemodynamics of the Circulatory Transition12. Oxygen During Postnatal StabilizationPart 3: Biology of Hypoxic Respiratory Failure in the Neonate13. Hypoxia and Pulmonary Artery Structure14. Animal Models of PPHN and Vasoconstrictor Signaling in Hypoxia15. Hypoxia and Endothelial Dysfunction in the Lung16. Effects of Hypoxia on Pulmonary Vascular Smooth Muscle Contraction and Relaxation17. Cellular Oxygen Sensing, Mitochondrial Oxygen Sensing and Reactive Oxygen Species18. Reactive Oxygen Species Signaling in Animal Models of Pulmonary Hypertension19. Hypoxia, Myocardial Metabolic Adaptation and Right Ventricular Performance20. Hypoxic Remodeling of Neonatal Pulmonary Artery and Myocardium21. Hypoxia-Induced Epigenetic Mechanisms of Pulmonary HypertensionPart 4: Hypoxia and Collateral Damage22. The Effects of Hypoxia Ischemia on the Term Brain, and A Strategic Approach23. Effects of Hypoxia on Cerebral Perfusion and the Blood-Brain Barrier24. Effects of Hypoxia on Airway, Alveolar Function and Respiration25. Hypoxic Respiratory Failure and the Neonatal Kidney26. The Effect of Hypoxia on Intestinal Function27. Effects of Hypoxia on Perinatal Drug Disposition28. Anesthetic Considerations for the Neonate with Hypoxic Respiratory FailurePart 5: Diagnosis and Management of Neonatal Hypoxic Respiratory Failure29. Epidemiology and Outcomes of Infants with Hypoxemic Respiratory Failure30. Clinical Evaluation of Hypoxic Respiratory Failure31. Diagnosis of Pulmonary Hypertension by Echocardiography32. Right Ventricular Performance and Ventricular Interdependence in Hypoxia33. Ventilation Strategies in Neonatal Hypoxemic Respiratory Failure34. Pulmonary Hypertension Phenotypes in the Newborn35. Special Consideration: HRF in Congenital Diaphragmatic Hernia36. Special Consideration: Hypoxemic Respiratory Failure Among Patients with Hypoxic Ischemic Encephalopathy37. Special Consideration: HRF in the Preterm38. Hypoxemic Respiratory Failure – Neonatal Cases

'This book elects to follow the thread of hypoxia, as an originating etiology and defining feature of neonatal pulmonary hypertension. It is a comprehensive and thematic volume of topical articles by world renowned authors, and has assembled all information pertinent to this topic in 38 chapters divided into 5 distinct sections, each marshalled by a dedicated co-editor. This strong interdisciplinary editorial team brings to bear complementary theoretical and practical expertise in different aspects of hypoxia and respiratory failure, and clearly a wide-ranging contact list – the book has over 80 contributing authors. Salient features of this book are helpful signaling pathway diagrams, conceptual illustrations, and synthesis figures by Satyan Lakshminrusimha.Reading the whole volume provides a satisfying continuous narrative of hypoxia through the evolutionary and developmental timeline, and deeper insight into what might appear to be only a superficial problem solved by turning up the oxygen dial. This book is therefore recommended to practicing clinicians as much as to scholars in this field of science.'Dr Kurt Stenmark'It is the most comprehensive discussion of this topic to be found anywhere in the literature. […] There are no comparable texts on this subject, although hypoxia and PPHN are discussed in every standard neonatal textbook. The five authors and the over 80 contributors are the world's research leaders in this topic and are to be congratulated on this superb publication.'Jay P. Goldsmith, MD (Tulane University School of Medicine), Doody Enterprises