Health Benefits of Nuts and Dried Fruits

Cesarettin Alasalvar, Ph.D., FIFT, FISNFF, is the Director of the Food Institute at TÜBİTAK Marmara Research Center (MRC) in Turkey and is also an Associate Professor of Food Science and Engineering. His research interests focus mainly on development of functional foods and nutraceuticals, nutritional and functional properties of foods, bioactive properties of phytochemicals, and separation and identification of bioactives as well as bioavailability of foods and human clinical trials. Dr. Alasalvar has been active in the Institute of Food Technologists (IFT) programs for many years and served as a past chair of the Nutraceuticals and Functional Foods Division. He was one of the co-founders of the International Society for Nutraceuticals and Functional Foods (ISNFF) and also served as a past president of ISNFF. Dr Alasalvar is an editor of Food Chemistry journal and serves as an editorial board member of Journal of Functional Foods, Journal of Food Bioactives, and Food Production, Processing and Nutrition journal. He is active in Horizon 2020 Programme and has served as Turkish Delegate of Societal Challenges II (Food Security, Sustainable Agriculture and Forestry, Marine, Maritime and Inland Water Research, and the Bio economy) of the Horizon 2020 Programme Committee since 2017. He is also the Scientific Advisory Board Member of PRIMA (Partnership for Research and Innovation in the Mediterranean Area – Horizon 2020) and serves on the Academic Committee and World Forum for Nutrition Research and Dissemination Committee Members of International Nut and Dried Fruit Council (INC). Dr Alasalvar is the editor of six books and holds five patents. His work has led to the publication of over 100 research articles in the form of peer-reviewed journals (h-index of 36) and book chapters. He has considerable experience in coordinating numerous national and European Union funded projects (FP7-NutraHEALTH and IPA-INNOFOOD). Dr Alasalvar has received a number of prestigious international awards, including the IFT-Fellow Award (2012), the TÜBİTAK MRC – Most Successful Researcher Award (2012), the ISNFF-Merit Award (2014), the Sabri Ülker International Science and Innovation Award on Food, Nutrition, and Health (2015), and the ISNFF-Fellow Award (2019) in recognition of his pioneering scientific achievements.Jordi Salas-Salvadó, M.D., Ph.D., is Professor of Nutrition, director of the Human Nutrition Research Unit at the Rovira i Virgili University (URV) and clinical head of the Nutrition Unit of the Internal Medicine Service of the Hospital Sant Joan de Reus, Spain. He is also the vice-president of the Pere i Virgili Health Research Institute, principal investigator of the Pathophysiology of Obesity and Nutrition Research Network at Instituto de Salud Carlos III, chairman of the World Forum for Nutrition Research and Dissemination (INC), director of the Catalan Center of Nutrition (CCNIEC), and member of the Network of Experts of the Public Health Agency of Catalonia (ACSA). Previously, he was a member of the Scientific Committee of the Spanish Agency for Food Safety, president of the Spanish Federation of Societies of Nutrition, Food, and Dietetics (FESNAD), and vice-dean – head of studies in Human Nutrition and Dietetics (URV). His research interests focus mainly on human clinical trials evaluating the effect of diet and dietary components on obesity, type-2 diabetes mellitus, metabolic syndrome, and cardiovascular disease (CVD). He is one of the leaders of the PREDIMED study, a landmark trial evaluating the effect of the Mediterranean Diet on the primary prevention of CVD. He is now the director and chair of the Steering Committee of the PREDIMED-PLUS study, an ongoing multi-center, randomized, and primary prevention trial on 6,900 overweight/obese participants with metabolic syndrome. He has directed more than 30 research projects funded by public agencies and 25 projects in collaboration with pharmaceutical and food industries. He is principal investigator or co-principal investigator of other projects funded by the Instituto de Salud Carlos III, the European Commission, and National Institutes of Health (USA). He has published more than 550 original research articles in peer-reviewed journals, has been editor of six books, and has co-authored more than 65 other books (h-index of 63 and more than 18,000 citations). He has also received an award as a highly cited researcher 2018 by Clarivate Analytics.Emilio Ros, M.D., Ph.D., is Emeritus Investigator, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain; founder and former head of the Lipid Clinic, Endocrinology, and Nutrition Department and Hospital Clinic, Barcelona; and former Principal Investigator of the research groups “Hypertension, Lipids, and Atherosclerosis” at IDIBAPS, Barcelona and “Nutrition, Lipids, and Cardiovascular Risk”, CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. He was founder and vice-president of Sociedad Española de Arteriosclerosis (SEA), founder and editor of the official journal of SEA “Clínica e Investigación en Arteriosclerosis,” and founder and president of Sociedad Iberoamericana de Aterosclerosis. He underwent postgraduate training in the USA (New York and Boston, 1970–1976) and was certified by the American Board of Internal Medicine and the American Board of Internal Medicine, subspecialty Gastroenterology. He is active member of the editorial boards of Metabolism and Nutrients, and former associate editor of the British Journal of Nutrition and Medicina Clínica (Barcelona). His research interests include nutrition in the prevention of cardiovascular diseases, age-related cognitive decline, and dementia, with especial interest in the Mediterranean diet and walnuts, plant sterols, blood membrane fatty acids, genetic dyslipidemias, cardiovascular risk assessment, and vascular imaging techniques. He also led the nutritional intervention of the landmark PREDIMED trial of Mediterranean diet for primary cardiovascular prevention and serves on the steering committees of the PREDIMED and PREDIMED Plus studies. Dr Ros has received numerous research grants from public and private agencies. He has published more than 380 original papers, over 130 review papers, 30 editorials, and 90 scientific textbook chapters (h-index of 61). He has been speaker at many scientific conferences and professor of many postgraduate courses in the fields of nutrition, lipid metabolism, atherosclerosis, and cardiovascular prevention. He received the award for best scientific career in Nutrition, Instituto Danone Spain 2013; the Grande-Covián Award for a life career in Nutrition, SEA 2014; the Excellence in Research Award, International Nut Council 2014; and the CCNIEC award for a life career in Nutrition, Barcelona 2015. He has also received an award as a highly cited researcher globally for the period 2006–2016 by Clarivate Analytics.Joan Sabaté, M.D., Dr.PH, is professor of Nutrition and Epidemiology at Loma Linda University School of Public Health where he directs the Center for Nutrition, Lifestyle, and Disease Prevention. Originally from Spain, Dr Sabaté is a boardcertified physician in Internal Medicine who moved to the USA to further train in Public Health Nutrition. He obtained a doctorate in Nutrition and a Fellowship in Nutritional Epidemiology. Dr Sabaté was the principal investigator of a nutrition intervention trial that directly linked the consumption of walnuts to significant reductions in serum cholesterol, published in the New England Journal of Medicine in 1993. The Archives of Internal Medicine later published his findings of a pooled analysis of 25 intervention trials establishing the benefits of nut consumption for blood lipid levels and lowering the risk of heart disease. He has been the principal investigator of over 30 clinical trials investigating the health effects of nuts and other plant foods, funded by public and private agencies. He enjoys conducting research and disseminating the findings. He has authored more than 200 research articles in the scientific literature, many of them in high-impact journals (h-index of 57 and more than 10,500 citations). Dr Sabaté is co-investigator of the Adventist Health Studies, prospective epidemiological studies relating dietary intake with health outcomes that have the largest cohorts of vegetarians. He is editor of the reference book Vegetarian Nutrition published by CRC Press, and was the principal architect of the Vegetarian Food Guide Pyramid released in 1987 at the 3rd International Congress on Vegetarian Nutrition and redesigned in 2008. He has been chair of the 4th–7th International Congress on Vegetarian Nutrition, and he edited the congress proceedings published in the American Journal of Clinical Nutrition. For the past 10 years, Dr Sabaté has directed the Environmental Nutrition research program at the Loma Linda University School of Public Health. This program focuses on sustainable diets and explores the interrelationships between the environmental and health impacts of food choices, and ultimately seeks to improve the sustainability, health, and equity of food systems. He is editor of the book Environmental Nutrition: Connecting Health and Nutrition with Environmentally Sustainable Diets, published by Elsevier.

• ContentsPREFACE IXEDITORS XICONTRIBUTORS XV1 Health Benefits of Nuts and Dried Fruits: An Overview 1CESARETTIN ALASALVAR, JORDI-SALAS SALVADÓ, EMILIO ROS, ANDJOAN SABATÉSection I NUTS2 Nuts:Nutrients, Natural Antioxidants, Fat-SolubleBioactives, and Phenolics 13CESARETTIN ALASALVAR, SUI KIAT CHANG, AND FEREIDOON SHAHIDI3 E ffect of Nut Consumption on Blood Lipids, Lipoproteins,and Apolipoproteins – Summary of the Evidence 59JOAN SABATÉ, EDWARD BITOK, AND SUJATHA RAJARAM4 Nuts and Cardio-Metabolic Syndrome (EndothelialFunction, Inflammation, and Blood Pressure) 91PABLO HERNÁNDEZ-ALONSO, MARTA GUASCH-FERRÉ, MÒNICA BULLÓ,AND JORDI SALAS-SALVADÓ5 T he Energetics of Nut Consumption: Oral Processing,Appetite, and Energy Balance 125BREANNA M. MCARTHUR, KELLY A. HIGGINS, STEPHANIE R. HUNTER,AND RICHARD D. MATTES6 Nut Consumption and Cardiovascular Disease 155TASNIM F. IMRAN AND LUC DJOUSSÉ7 Nut Consumption and Adiposity 167MAIRA BES-RASTROLLO AND MIGUEL ÁNGEL MARTÍNEZ-GONZÁLEZ8 Nuts in the Prevention and Management of Diabetes 181STEPHANIE K. NISHI, EFFIE VIGUILIOUK, SONIA BLANCO MEJIA, DAVIDJ.A. JENKINS, JOHN L. SIEVENPIPER, AND CYRIL W.C. KENDALL9 Nut Consumption and Cancer 223HEINZ FREISLING AND HWAYOUNG NOH10 Nut Consumption and All-Cause and Cause-SpecificMortality and Longevity: A Review of the Evidence 247DAGFINN AUNE11 Nuts and Brain Health: Cognition, Depression, andNeurodegenerative Diseases 261EMILIO ROS AND ALEIX SALA-VILA12 Nuts in Healthy Dietary Patterns andDietary Guidelines 289ELIZABETH P. NEALE AND LINDA C. TAPSELL13 Nuts: Gut Health and Microbiota 313SERENA GALIÈ, MÒNICA BULLÓ, ALESSANDRO ATZENI, PABLOHERNÁNDEZ-ALONSO, JANANEE MURALIDHARAN, AND JORDISALAS-SALVADÓSection II DRIED FRUIT S14 Dried Fruits: Nutrients, Natural Antioxidants, andPhytochemicals 335CESARETTIN ALASALVAR, SUI KIAT CHANG, AND FEREIDOON SHAHIDI15 Bioavailability of Nutrients and Phytochemicalsfrom Dried Fruits 369ARIANNA CARUGHI, DANIEL GALLAHER, AND GIUSEPPINA MANDALARI16 E ffect of Dried Fruits on Lipid Profiles (Dose–Response,Effects on Different Groups and Different Dried Fruits,and Cardiovascular Diseases) 397CHELSEA GARCIA AND CHRISTOPHER N. BLESSO17 Dried Fruits and Cardio-Metabolic Syndrome(Endothelial Function, Inflammation,and Blood Pressure) 413VALERIE SULLIVAN, KRISTINA PETERSEN, ANDPENNY KRIS-ETHERTON18 Dried Fruits in the Prevention and Control of Diabetes(Insulin Resistance and Prediabetes) 437KRISTIE (KORBUA) SRICHAIKUL, MELODY ONG, ZOHA PRASLA, YAKUPKOHEN, IRIS MANDALOZANO, MELANIE PAQUETTE, SANDHYA SAHYEPUDARUTH,DARSHNA PATEL, CYRIL W.C. KENDALL, JOHN L. SIEVENPIPER,AND DAVID J.A. JENKINS19 Dried Fruit Consumption and Cancer 449BRADLEY BOLLING, XIAOCAO LIU, AND JIYUAN LIU20 Dried Fruits: Bone Health and Osteoprotection 469BAHRAM H. ARJMANDI AND KELLI S. GEORGE21 Dried Fruits: Gut Health and Microbiota 487MARÍA MARHUENDA MUÑOZ AND ROSA M. LAMUELA RAVENTÓS22 Other Health Benefits of Dried Fruits: CognitiveFunction, Appetite, Satiety Control, Intestinal Health,and Hepatoprotection 497JIE LIU, ZIYUAN WANG, AND MINGSI XIE23 Dried Fruits as Components of Health Dietary Patterns 513ANA PAULA SILVA CALDAS AND JOSEFINA BRESSANINDEX 527