GPCRs as Therapeutic Targets

Annette Gilchrist, PhD, is an Associate Professor at Midwestern University in the Department of Pharmaceutical Sciences.

• Chapter 1 - An overview of G protein coupled receptors and their signaling partnersChapter 2 - Recent advances in orphan GPCRs research and therapeutic potentialChapter 3 - The Evolution of Our Understanding of GPCRsChapter 4 - Approaching GPCR dimers and higher order oligomers using biophysical, biochemical and proteomic methodsChapter 5 - Arrestin and G protein interactions with GPCRs: a structural perspectiveChapter 6 - GPCRs at endosomes: sorting, signaling, and recyclingChapter 7 - Post-translational Control of GPCR SignalingChapter 8 - GPCR Signaling from Intracellular MembranesChapter 9 - Ten years of GPCR structuresChapter 10 - Activation of class B GPCR by peptide ligands: general structural aspectsChapter 11 - Dynamical basis of GPCR-G-protein coupling selectivity and promiscuityChapter 12 - Virtual Screening and Bioactivity Modeling for G Protein‐Coupled ReceptorsChapter 13 - Importance of structure and dynamics in the rational drug design ofG protein-coupled receptor (GPCR) modulatorsChapter 14 - Signaling, Physiology and Targeting of GPCR-Regulated Phospholipase C EnzymesChapter 15 - G Protein-coupled Receptors in Metabolic DiseaseChapter 16 - Endothelin Receptors in cerebrovascular diseasesChapter 17 - The calcium-sensing receptor (CaSR) in diseaseChapter 18 - G protein-coupled receptors and their mutations in cancer – a focus on adenosine receptorsChapter 19 - Dopamine Receptors: Neurotherapeutic Targets for Substance Use DisordersChapter 20 - PTHR1 in boneChapter 21 - Activators of G-protein Signaling in the normal and diseased kidneyChapter 22 - Screening and characterization of GPCR-ligand interactions with mass spectrometry-based technologiesChapter 23 - Bioluminescence resonance energy transfer (BRET) technologies to study GPCRsChapter 24 - The Application of 19F NMR to Studies of Protein Function and Drug ScreeningChapter 25 - Chapter X: Optical Approaches for Dissecting GPCR SignalingChapter 26 - GPCR Signaling in Nanodomains: Lessons from Single-Molecule Microscopy