GERD

Dr. Parakrama Chandrasoma was born in Sri Lanka and received his medical education and initial pathology training in the Medical School of the University of Sri Lanka. He has postgraduate degrees in internal medicine, including the M.D. (Sri Lanka) and Membership of the Royal College of Physicians (UK). He immigrated to the United States in 1978. Upon completing his pathology residency, he assumed duties as Chief of Surgical Pathology at the Los Angeles County + University of Southern California Medical Center He has held this position since. After an initial interest in neuropathology, Dr. Chandrasoma joined Dr. Tom DeMeester’s Foregut Surgery team as pathologist in 1991. This led to a productive study of gastroesophageal reflux disease spanning 16 years and resulting in the development of numerous original concepts relating to the pathogenesis of gastroesophageal reflux disease. Dr. Chandrasoma has written over 140 peer reviewed papers and 6 previous pathology textbooks, including a general text on Gastrointestinal Pathology and a text on Gastroesophageal Reflux Disease, and is a Professor of Pathology at the Keck School of Medicine at the University of Southern California. He is married with three children and lives in Pasadena, California.

• 1. Definition of Gastroesophageal Reflux Disease: Past, Present and Future2. Present Diagnosis and Management of Gastroesophageal Reflux Disease: The Good, Bad and Ugly3. Fetal and Postnatal Development of the Esophagus and Proximal Stomach4. Histologic Definition and Diagnosis of Epithelia in the Esophagus and Proximal Stomach5. Definition of the Normal State – A Yet Unfinished Saga6. Definition of the Gastroesophageal Junction7. The Normal Lower Esophageal Sphincter8. The Pathogenesis of Early GERD9. Correlation of LES Damage and GERD10. The Effect of Damage to the Abdominal Segment of the LES: The Dilated Distal Esophagus11. Columnar-Lined Esophagus (Microscopic and Visible) and Barrett Esophagus12. Esophageal Adenocarcinoma13. Progression of GERD at the Clinical Level 14. Progression of GERD at a Pathological Level 15. Molecular Evolution of Esophageal Epithelial Metaplasia 16. Progression of GERD From the Perspective of LES Damage17. New Pathologic Test of LES Damage18. New Method of Functional Assessment of the LES19. Prediction of Future Progression of LES Damage20. Proof of Concept of the New Diagnostic Method21. Application of the New Method to Present and Future Management of GERD

"the book orchestrates a fascinating firework of impressive novelty, actuality, and relevance, and is highly recommended to those who areinvolved in the diagnosis, treatment, and management of GERD and BE. May the book help you to improve and restore the life quality and wellbeing of your patients." --European Surgery