GERD

Dr. Parakrama Chandrasoma was born in Sri Lanka and received his medical education and initial pathology training in the Medical School of the University of Sri Lanka. He has postgraduate degrees in internal medicine, including the M.D. (Sri Lanka) and Membership of the Royal College of Physicians (UK). He immigrated to the United States in 1978. Upon completing his pathology residency, he assumed duties as Chief of Surgical Pathology at the Los Angeles County + University of Southern California Medical Center He has held this position since. After an initial interest in neuropathology, Dr. Chandrasoma joined Dr. Tom DeMeester’s Foregut Surgery team as pathologist in 1991. This led to a productive study of gastroesophageal reflux disease spanning 16 years and resulting in the development of numerous original concepts relating to the pathogenesis of gastroesophageal reflux disease. Dr. Chandrasoma has written over 140 peer reviewed papers and 6 previous pathology textbooks, including a general text on Gastrointestinal Pathology and a text on Gastroesophageal Reflux Disease, and is a Professor of Pathology at the Keck School of Medicine at the University of Southern California. He is married with three children and lives in Pasadena, California. Professor of Clinical Surgery and Chair of the Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

• Chapter 1: Overview of Gastroesophageal Reflux DiseaseChapter 2: The Past, Present, and Future of Columnar-Lined (Barrett) EsophagusChapter 3: Fetal Development of the Esophagus and StomachChapter 4: Normal Anatomy; Present Definition of the Gastroesophageal JunctionChapter 5: Histologic Definitions and Diagnosis of Epithelial TypesChapter 6: Cardiac MucosaChapter 7: New Histologic Definitions of Esophagus, Stomach, and Gastroesophageal JunctionChapter 8: Pathology of Reflux Disease at a Cellular Level: Part 1—Damage to Squamous Epithelium and Transformation into Cardiac MucosaChapter 9: The Pathology of Reflux Disease at a Cellular Level: Part 2—Evolution of Cardiac Mucosa to Oxyntocardiac Mucosa and Intestinal MetaplasiaChapter 10: Pathology of Reflux Disease at a Cellular Level: Part 3—Intestinal (Barrett) Metaplasia to CarcinomaChapter 11: Pathology of Reflux Disease at an Anatomic LevelChapter 12: Reflux Disease Limited to the Dilated End-Stage Esophagus: The Pathologic Basis of NERDChapter 13: Definition of Gastroesophageal Reflux Disease and Barrett EsophagusChapter 14: Diagnosis of Gastroesophageal Reflux Disease, Barrett Esophagus, and DysplasiaChapter 15: Research Strategies for Preventing Reflux-Induced AdenocarcinomaChapter 16: Rationale for Treatment of Reflux Disease and Barrett EsophagusChapter 17: Treatment Strategies for Preventing Reflux-Induced AdenocarcinomaIndex

“This is the most comprehensive book ever written about gastroesophageal reflux disease. Dr. Tom R. DeMeester has been the leading authority on this disease of the 20th century, and has headed for the last 15 years one of the most productive units of foregut surgery in the world. Dr. Chandrasoma has recently emerged as a leading pathologist in this area. The authors have extensively covered all aspects of gastroesophageal reflux disease, from the anatomy to the pathophysiology, from the diagnosis to the rationale for treatment. They have carefully reviewed the literature in view of their own experience, explaining how this disease can progress from symptoms to cancer. An essential reading for whoever treats patients with gastroesophageal reflux disease, from gastroenterologists to surgeons.” --Marco G. Patti, MD, Professor of Surgery, University of California, San Francisco"One would be hard pressed to find a better collaboration to characterize the total clinical spectrum of esophageal adenocarcinoma than Tom DeMeester and Para Chandrasoma. This textbook is rich with the fruits of the knowledge and experience of these two outstanding investigators, including not only the full range of commonly accepted knowledge and beliefs in this field but also developing concepts on the histopathologic relationship between chronic reflux and injury to the distal esophageal mucosa that have resulted from detailed observation and clinical research from this illustrious team. Failure to appreciate the histologic changes that occur with, and therefore predict, the process of development of adenocarcinoma leave the clinician with a false sense of understanding. As the authors state, “most influential physicians on the subject today simply do not look through the microscope and have no true understanding of histology.” The approach that this team follows at the University of Southern California is based on their belief that “to be successful, the super specialized clinical esophagologist must understand the significance of the microscopic pathology of the biopsies that are taken, and the super specialized esophageal pathologist must understand the clinical basis of columnar-lined esophagus." All of us who are involved in the care of patients with esophageal adenocarcinoma owe a debt of gratitude to Drs. DeMeester and Chandrasoma for producing the exceptional material contained within this text." --Donald O. Castell, MD, Professor of Medicine, Director, Esophageal Disorders Program, Medical University of South Carolina“Everyone interested in esophageal disease should read this book. It is unlike any other I have ever read on the subject and is likely the most controversial and thought provoking of any on this disease. The book represents the collected experience and opinions of the book’s 2 authors – an accomplished pathologist (Dr. Chandrasoma) and arguably the most accomplished esophageal surgeon of his time (Dr. DeMeester) – who have worked together at the same institution for approximately 15 years in a surgical esophageal and foregut group that sees complex and difficult gastroesophageal reflux disease (GERD) cases. This book is extremely well written, carefully and thoughtfully prepared, and offers the open-minded reader a view of GERD that they would not read in any standard textbook or review article on the subject. The rich descriptions of the histopathology, views on carditis, cardiac intestinal metaplasia; and the microscopic definition of the gastroesophageal junction are valuable to all that study this disease.” --Philp O. Katz, Thomas Jefferson University and Albert Einstein Medical Center, Philadelphia, PA, Gastroenterology, 2007