Extracellular Vesicle-Based Biovectors for Diagnostic and Biomedical Applications

Dr. Arun Kumar is currently an Assistant Professor in the Department of Pharmacy at Central University of South Bihar, Gaya, India. He earned a PhD from the Department of Pharmacy at Jaypee University of Information Technology, Waknaghat, Solan, India. He has more than 11 years of combined research and teaching experience, and his work focuses on smart and responsive materials, 3D printing, microneedles, extracellular-based drug delivery, antimicrobial compounds, and nanostructures for various biomedical applications, including tissue regeneration, drug delivery, and cancer therapy. He has actively collaborated with researchers in other disciplines of pharmaceutical sciences, particularly the nanoformulations of drugs for drug delivery systems and nanomedicine. His work has resulted in the publication of over 60 peer-reviewed journal articles in prestigious journals, including International Journal of Biological Macromolecules, Advanced Healthcare Materials, Seminars in Cancer Biology, Journal of Material Chemistry B, and Bioengineering and Translational Medicines. He has also author over five book chapters and has files five patents filed.Dr. Charan Singh is currently an Assistant Professor of Pharmaceutics at HNB Garhwal University (A Central University), Srinagar Garhwal, Uttarakhand, India. He received his PhD in Pharmaceutical Technology (Formulation) from the National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Punjab, India. He was later a National Postdoc Fellow at Panjab University, Chandigarh, India and an IBRO-Exchange Fellow at the University of Queensland in Brisbane, Australia. He has received a number of other fellowships and awards such as the IBRO Early Career Award and the SERB-SIRE Fellowship. Dr. Singh’s research interests include the design, synthesis, characterization, and evaluation of lipidic and polymeric nanomaterials for drug delivery and targeting to improve the treatment and diagnosis of human diseases. Dr. Singh has one patent (granted) and has published book chapters and more than 50 publications in international journals such as Journal of Controlled Release, Asian Journal of Pharmaceutical Sciences, Carbohydrate Polymers, Drug Delivery Sciences and Technology, International Journal of Pharmaceutics. Dr. Ajeet Kaushik is Associate Professor at the NanoBioTech Laboratory, Department of Environmental Engineering, Florida Polytechnic University, USA. He is the recipient of various reputed awards for his service in the area of nano-biotechnology for health care. He has edited seven books, written more than 100 international research peer reviewed publications, and has three patents in the area of nanomedicine and smart biosensors for personalized health care. In the course of his research, Dr. Kaushik has been engaged in the design and development of various electro-active nanostructures for electrochemical biosensor and nanomedicine for health care. His research interests include nanobiotechnology, analytical systems, design and develop nanostructures, nano-carries for drug delivery, nano-therapeutics for CNS diseases, on-demand site-specific release of therapeutic agents, exploring personalized nanomedicines, biosensors, point-of-care sensing devices, and related areas of health care monitoring.

• Part I: Introduction: Extracellular vesicles origin, classifications and biosynthesis, isolation approaches, purification, and functionalization of extracellular vesicles for biomedical applications and new perspectives1. Introduction to extracellular vesicles: origin, classification, and biosynthesis2. Isolation, purification, and challenges in extracellular vesicles3. Characterization of extracellular vesicles: techniques and technologies4. Drug loading techniques for extracellular vesicles for biomedical applications5. Functionalization of extracellular vesicles for biomedical applicationsPart II: Therapeutic applications of extracellular vesicles6. Extracellular vesicles in musculoskeletal and cardiovascular applications7. Extracellular vesicles in neurodegenerative diseases8. Extracellular vesicles in autoimmune diseases and immunotherapy9. Extracellular vesicles in diabetes mellitus and metabolic syndrome10. Extracellular vesicles in cancer therapy11. Emerging applications of extracellular vesicles in regenerative medicine and tissue engineering12. Biocompatibility, safety, and challenges in commercial, regulatory, and clinical translationPart III: Diagnostic applications of extracellular vesicles in biomedical research13. Extracellular vesicles as diagnostic biomarkers in cancer research14. Extracellular vesicles in the diagnosis of diabetes mellitus and associated complications15. Diagnostic application of extracellular vesicles as biomarkers in neurological disorders16. Prognostic and diagnostic applications of extracellular vesicles in cardiovascular diseases17. Extracellular vesicles in the diagnosis of autoimmune diseases18. Emerging technologies and future directions in extracellular vesicle research