Evidence-Based Pediatric Oncology

Edited byRoss Pinkerton, MB, BCh, BaO, MD, Executive Director, Division of Oncology, Royal Children’s Hospital, Children’s Health Queensland, Brisbane, QLD, AustraliaAnanth Shankar, MD, FRCPCH, Consultant in Paediatric and Adolescent Oncology, University CollegeLondon Hospitals NHS Foundation Trust, London, UKKatherine K. Matthay, BA, MD, Mildred V. Strouss Professor of Translational Oncology, Director, Pediatric Hematology-Oncology, Department of Pediatrics, UCSF School of Medicine and UCSF Benioff Children’s Hospital, San Francisco, CA, USA

• List of contributors, viiPreface, ixList of abbreviations, xAbout the companion website, xvPart 1: Solid tumors1 Rhabdomyosarcoma, 3Katherine K. Matthay(Commentary by Meriel Jenney)2 Osteosarcoma, 14Katherine K. Matthay(Commentary by Maria Michelagnoli)3 Ewing sarcoma, 25Katherine K. Matthay(Commentary by Steven G. DuBois)4 Wilms tumor, 34Ananth Shankar(Commentary by Kathy Pritchard-Jones)5 Neuroblastoma, 47Katherine K. Matthay(Commentary by Katherine K. Matthay)6 Hepatoblastoma, 58Ross Pinkerton(Commentary by Penelope Brock)7 Malignant germ cell tumors, 65Ross Pinkerton(Commentary by Ross Pinkerton)8 Medulloblastoma, 69Ross Pinkerton(Commentary by Eric Bouffet)9 Glioma, 81Ross Pinkerton(Commentary by Joann L. Ater)10 Non-Hodgkin lymphoma, 88Ross Pinkerton(Commentary by Ross Pinkerton)11 Hodgkin lymphoma, 105Ross Pinkerton(Commentary by Cindy L. Schwartz)Part 2: LeukemiaSection 1: Acute myeloid leukemia 12 Acute myeloid leukemia commentary, 119Robert J. Arceci13 Remission induction in acute myeloid leukemia, 126Ananth Shankar14 Acute myeloid leukemia consolidation, 135Ananth Shankar15 Maintenance treatment in acute myeloid leukemia, 137Ananth Shankar16 Autologous bone marrow transplantation in acute myeloid leukemia, 141Ananth Shankar17 Acute myeloid leukemia: miscellaneous, 144Ananth ShankarSection 2: Childhood lymphoblastic leukemia18 Childhood lymphoblastic leukemia commentary, 146Vaskar Saha19 Remission induction in childhood lymphoblastic leukemia, 154Ananth Shankar20 Central nervous system-directed therapy in childhood lymphoblastic leukemia, 168Ananth Shankar21 Maintenance treatment in childhood lymphoblastic leukemia, 180Ananth Shankar22 Relapsed childhood lymphoblastic leukemia, 198Ananth Shankar23 Postinduction therapy in adolescents and young adults with acute lymphoblastic leukemia, 204Ananth ShankarPart 3: Supportive care in pediatric oncology24 Colony-stimulating factors, 209Ananth Shankar(Commentary by Victoria Grandage)25 Cardioprotection in pediatric oncology, 230Ananth Shankar(Commentary by Gill A. Levitt)26 Infections in pediatric and adolescent oncology, 243Ananth Shankar and Sara Stoneham(Commentary by Julia E. Clark)Index, 269