Edited by Philipp Dahm, MD, MHSc, Director for Surgery/Specialty Care Service Line Research Activities, Minneapolis VA Health Care System and Professor of Urology, University of Minnesota, Minneapolis, Minnesota Roger Dmochowski, MD, Professor of Urologic Surgery, Department of Urology Vice Chair of the Section of Surgical Sciences and Associate Surgeon in Chief, Vanderbilt University Medical Center, Nashville, Tennessee.

• Part 1 Evidence‐based methodsPhilipp Dahm1 Searching for evidence, 3Jeanette Buckingham2 Clinical trials in urology, 19Charles D. Scales, Jr. and David F. Penson3 Systematic reviews in urology, 25Philipp Dahm, Shahnaz Sultan, and Jae Hung Jung4 Rating the quality of evidence and making recommendations, 39Philipp Dahm and Shahnaz Sultan5 Evidence‐based clinical practice guidelinesin urology, 47Steven E. Canfield6 Understanding concepts related to health economics in urology, 53Yair Lotan and Ryan Hutchinson7 Quality improvement in urology, 59Nima Almassi and Howard B. GoldmanPart 2 General urology and stone diseaseCharles D. Scales, Jr.8 Antibiotic prophylaxis in urological surgery, 67Roderick Clark and Philippe Violette9 Venous thromboembolism (VTE) prophylaxis, 89Vikram Narayan and Philipp Dahm10 Operative safety, 103Elizabeth Timbrook Brown, Bryan J. Hill, and Roger R. Dmochowski11 Prophylaxis and treatment of urinary tract infections in adults, 113Gabrielle J. Williams, Angela C. Webster, and Jonathan C. Craig12 Medical management of stone disease, 133Timothy Y. Tseng and Glenn M. Preminger13 Surgical management of renal stone disease, 159Justin M. Dersch, Brandon J. Otto, and Benjamin K. Canales14 Surgical management of ureteral stone disease, 171Aaron H. Lay, Jay D. Raman, and Margaret S. PearlePart 3 Pediatric urologyLuis H.P. Braga15 Prenatal hydronephrosis, 187Shawn Dason and Luis H.P. Braga16 Cryptorchidism, 197David I. Chu and Gregory E. Tasian17 Vesicoureteral reflux disease, 209Ruiyang Jiang and Jonathan C. Routh18 Circumcision, 217Roderick Clark and Sumit Dave19 Nocturnal enuresis, 235Stacy T. Tanaka20 Management of neurogenic bladder in children with spina bifida, 243Kourosh Afshar, Mir Sohail Fazeli, and Cyrus Chehroodi21 Wilms tumor, 251Ruiyang Jiang and Jonathan C. RouthPart 4 Prostate cancerJulio M. Pow-Sang22 Early detection and screening for prostate cancer, 257Pim J. van Leeuwen, Monique J. Roobol, and Phillip D. Stricker23 Molecular markers for prostate cancer, 265Pranav Sharma, Eric Webb, and Julio M. Pow‐Sang24 Imaging of the prostate, 279Matthew J. Watson, Francesca V. Mertan, Samuel Borofsky, Arvin K. George,Abhinav Sidana,Peter L. Choyke, Peter A. Pinto, and Baris Turkbey25 Active surveillance for localized prostate cancer, 289Nathan Perlis and Laurence Klotz26 Surgical management of prostate cancer,297Daniel A. Barocas and Michael S. Cookson27 Radiation therapy for clinically localized prostate cancer, 317Michelle Echevarria, Peter A. Johnstone, and Kosj Yamoah28 Management of metastatic prostate cancer, 331Michael S. Humeniuk, Tian Zhang, Megan A. McNamara,Sundhar Ramalingam, and Michael R. HarrisonPart 5 Kidney and bladder cancerRodney H. Breau29 Treatment of superficial bladder cancer, 349Alexander Kretschmer, Alexander Karl, and Badrinath R. Konety30 Treatment of muscle‐invasive bladder cancer, 367Justin R. Gregg and Sam S. Chang31 Management of upper tract urothelial carcinoma, 373Ilaria Lucca, Romain Mathieu, Tobias Klatte, and Shahrokh F. Shariat32 Metastatic bladder cancer, 383Louise Harris, Caitlin Bowen, Satish Kumar, Bernadette Coles, and Malcolm Mason33 Treatment of localized kidney cancer, 391Luke T. Lavallée, Frédérick Pouliot, and Rodney H. Breau34 Treatment of metastatic kidney cancer, 399Przemyslaw W. Twardowski and Robert A. FiglinPart 6 Testis and penile cancerMichael C. Risk35 Early‐stage (stage I) seminoma, 409Sia Daneshmand and Cory Hugen36 Advanced (stage II and III) and recurrent seminoma, 417Peter C. Black and Christian Kollmannsberger37 Early‐stage nonseminomatous germ‑cell tumor, 427Justin T. Matulay and James M. McKiernan38 Advanced nonseminoma, 443Michael C. Risk and Clint Cary39 Penile cancer, 457Oliver W. HakenbergPart 7 Female urology, trauma, and reconstructionRoger R. Dmochowski40 Medical management of urinary incontinence in women, 467Joshua A. Cohn, Elizabeth Timbrook Brown, W. Stuart Reynolds, Melissa R. Kaufman,Roger R. Dmochowski41 Surgical treatment of female urinary incontinence, 479Alex Gomelsky42 Diagnosis and treatment of overactive bladder, 489Nadir I. Osman, Altaf Mangera, and Christopher R. Chapple43 Urethral stricture disease, 497Robert A. Goldfarb and Sean P. Elliott44 Genitourinary trauma, 503Paul Chung and Bryan B. VoelzkePart 8 Male LUTS and sexual dysfunctionJohn M. Hollingsworth45 Medical management of benign prostatic hyperplasia, 511Paholo G. Barboglio Romo and John M. Hollingsworth46 Surgical management of lower urinary tract symptoms secondary to benign prostatic hypertrophy, 527Derek J. Lomas and Amy Krambeck47 Chronic prostatitis/chronic pelvic pain syndrome (NIH category III), 539Giuseppe Magistro and Florian M.E. Wagenlehner48 Management of erectile dysfunction, 545Hunter Wessells49 Update on treatment of bladder pain syndrome: does anything work? 555Yahir Santiago‐Lastra, Ann Oldendorf, and J. Quentin Clemens50 Male infertility, 561Bryan Hinck, Ashok Agarwal, Fnu Deepinder, and Edmund S. Sabanegh, Jr.51 Premature ejaculation, 569Josip Vukina, J. Abram McBride, Culley C. Carson, and R. Matthew CowardIndex 579

"This is a valuable book for all who care for urological patients. Every provider should have a foundation in evidence-based medicine and be familiar with interpreting and applying clinical knowledge to patient care. This book helps readers to achieve both. It addresses today's most relevant clinical questions in a manner that enables readers to practice evidence-based medicine skills." - Doody's Book Review, April 2019