John W. Miller, MD, PhD, University of Washington, Seattle, WA, USAHoward P. Goodkin, MD, PhD, University of Virginia, Charlottesville, VA, USA

• Contributor List ixSeries Foreword xiiiPreface xvPart I: Epilepsy Basics1 Recognizing Seizures and Epilepsy: Insights from Pathophysiology 3Carl E. Stafstrom2 Classifying Epileptic Seizures and the Epilepsies 10Valeria M. Muro and Mary B. Connolly3 What Causes Epilepsy? 15Anna Rosati and Renzo Guerrini4 Epidemiology of Seizures and Epilepsy 28Aidan Neligan and Josemir W. SanderPart II: Working up Seizures and Epilepsy5 Diagnosing and Localizing Seizures at the Bedside and in Clinic 35Joseph I. Sirven6 Psychogenic Nonepileptic Episodes 42Vaishali S. Phatak7 What Can the EEG Tell Us? 45Mark Quigg8 What Can Neuroimaging Tell Us? 54Edward J. Novotny9 Workup of New-Onset Seizures 61Jennifer Langer10 Evaluation of the Patient with Medically Refractory Epilepsy 67Gregory L. HolmesPart III: Using Antiepileptic Medications11 Choosing, Initiating, Adjusting, and Changing Antiepileptic Medications 77John W. Miller12 Antiepileptic Drug Adverse Effects: What to Watch Out For 84Jacquelyn L. Bainbridge and Caleb Y. Oh13 Antiepileptic Drug Interactions 91Philip N. Patsalos14 Recognizing Intractability to Antiepileptic Medication 102Bassel W. Abou-Khalil15 Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy 107Nicholas P. Poolos16 Rescue Medications for Home Treatment of Acute Seizures 112Peter Wolf and Rûta Mameniškienë17 When and How to Stop Antiepileptic Drugs 118John D. Hixson18 Using Parenteral Antiepileptic Medications 122Jane G. Boggs19 Pharmacopeia 126Gail D. AndersonPart IV: Special Topics in Pediatric Epilepsy20 Seizures in the Neonate 141Adam L. Hartman and Frances J. Northington21 Benign and Malignant Childhood Epilepsies 147Katherine C. Nickels and Elaine C. Wirrell22 Epilepsy: When to Perform a Genetic Analysis 159Heather E. Olson and Annapurna Poduri23 Metabolic Disorders Not to Miss 167Phillip L. Pearl and Yuezhou Joe YuPart V: Special Topics in Adult Epilepsy24 Juvenile Myoclonic Epilepsy and Other Primary Generalized Epilepsies 177Shahin Hakimian25 Epilepsy in Women of Childbearing Age 184Autumn Klein26 Epilepsy After Sixty 189Edward FaughtPart VI: What can be done when medication doesn’t work?27 When Should Epilepsy Neurosurgery Be Considered, and What Can It Accomplish? 199Paul A. Garcia28 When Should Vagus Nerve Stimulation Be Considered, and What Can It Accomplish? 205Pearce J. Korb and Sandra L. Helmers29 Ketogenic Diet and Alternative Therapies 210Dana Ekstein and Steven C. SchachterPart VII: How are acute seizures and status epilepticus evaluated and treated in the emergency department and the hospital?30 acute Symptomatic Seizures in Children and Adults: Evaluation and Treatment 217J. Stephen Huff and Jessica L. Carpenter31 Evaluating and Treating Status Epilepticus 222Jeffrey Bolton and Howard P. Goodkin32 Recognizing, Assessing, and Treating Seizures and Status Epilepticus in the ICU 227Nicolas Gaspard and Lawrence J. HirschPart VIII: The morbidity and mortality of epilepsy33 mortality in Epilepsy 243Elizabeth J. Donner34 Accidents in Epilepsy 248Allan Krumholz and Ana M. Sanchez35 Medical Comorbidity in Epilepsy 253Kimberly L. Pargeon and Sheryl R. Haut36 Cognitive Effects of Chronic Epilepsy 260Daniel L. Drane37 Recognizing and Treating Psychiatric Comorbidity in Epilepsy 268Jay SalpekarIndex 275Color plate section between pages 80 and 81

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