Drug Transporters

Dr Glynis Nicholls has over 18 years experience within the pharmaceutical field in both academia and industry (including 7 years at GlaxoSmithKline and 5 years at AstraZeneca), specializing in drug transporter science from discovery through to clinical development. Dr Nicholls has played a leading role in writing and implementing internal transporter strategies within the industry, as well as collaborating across multiple international locations with internal and external colleagues on transporter-related projects and scientific developments, including PhD projects. Dr Kuresh Youdim has 9 years academic experience in the field of nutrition and neuroscience, plus 10 years pharmaceutical experience across multiple disciplines within drug discovery and development (including 8 years at Pfizer and 2 years at Roche) predominantly in the field of drug-drug interactions and PBPK modelling.

• Overview of drug transporter families and their role in drug development;Liver transporters and their involvement in the hepatocellular uptake and export systems of organic anions;Intestinal transporters;Kidney transporters;CNS transporters;Lung transporters;The use of in vitro and in silico systems for investigating transporter interactions;The use of transgenic and knockout in vivo systems for investigating transporter interactions;Modelling and simulation of transporter interactions;Clinical Drug-Drug Interactions: An industrial Pharmaceutical Perspective;Regulatory requirements, Labelling and Drug Transporters;Recent Advances and Emerging Technologies;Bioinformatics;Regulation of transporters;Transporter Pharmacogenomics;Transporter Imaging;Transporters and Proteomics