DNA Methylation

• Describing the relation DNA methylation has to gene silencing in disease, this book explores its promising role in treating cancer. Written by leaders in the field, it outlines the best techniques to use when addressing questions concerning the cytosine methylation status of genomic DNA. Including concepts, experimental models, and clinical uses of demethylating agents, the book provides articles clarifying methodological details and more general review chapters that offer broad biological perspectives on DNA methylation. This is an invaluable handbook for researchers and clinicians interested in genetics and molecular biology, particularly epigenetic therapies and gene silencing.

"… written by leaders in the field. … interesting for both researchers and clinicians. It is an excellent summary of the subject for scientists starting in the field of epigenetics and it is also a reference book for professionals already familiar with the subject." – Assam El-Osta, Baker Heart Research Institute, Australia in CHEMMEDCHEM, 3, 2008