This volume discusses the intersection of digital transformation and innovation in firms, sectors, and regions in Latin America. It addresses the region’s labor market challenges in the advent of the digital era and the influences of AI. The chapters cover topics ranging from education, organizational culture, sustainability, ethics, and human resources. Exploring how digital and STEM literacies can serve as a tool for developing skills in organizations and emphasizing the need for human adaptability in the context of Industry 5.0, this book provides scholars with case studies to better understand the ongoing debates on labor market challenges.Antonia Teran-Bustamante is Professor at the School of Economics and Business Administration at Universidad Panamericana, Mexico and member of the Mexican National System of Researchers by SECIHTI.Marisol Velázquez Salazar is Professor and Associate Dean of Research at the School of Economics and Business Administration at Universidad Panamericana, Mexico and member of the Mexican National System of Researchers by SECIHTI