A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, DSc, FMed Sci, is Emeritus Professor of Haematology at University College, London, UK. Paresh Vyas, FRCP, FRCPath, DPhil, is Professor of Haematology, Director of Oxford Centre for Haematology, Honorary Consultant Haematologist and Group Leader, MRC Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Elías Campo, MD, is Senior Consultant and Research Director, Hospital Clinic of Barcelona, and Professor of Anatomical Pathology at University of Barcelona, Faculty of Medicine, Barcelona, Spain. Torsten Haferlach, MD, MLL Munich Leukemia Laboratory, Munich, Germany. Keith Gomez, MBBS, MRCP, FRCPath, PhD, is Consultant Haematologist at Royal Free London NHS Foundation Trust, UK.

• Preface xxx1 Molecular Biology of the Cell2 Hematopoiesis3 Growth Factor Signaling4 Erythropoiesis and Examination of the Peripheral Blood and Bone Marrow5 Hypochromic Anemias6 The Porphyrias and Iron Overload7 Megaloblastic Anemias8 Hemolytic Anemias9 Genetic Disorders of Hemoglobin10 Benign Disorders of Phagocytes11 Benign Disorders of Lymphocytes and Plasma Cells12 Aplastic and Dyserythropoietic Anemias13 The Hematologic Neoplasms: Laboratory Techniques and Acute Myeloid Leukemia14 Acute Lymphoblastic Leukemia15 Myelodysplastic Syndromes16 Myeloproliferative Neoplasms17 Mastocytosis, Myeloid/Lymphoid Neoplasms with Eosinophilia and Specific Cytogenetic Rearrangements, Myelodysplastic/Myeloproliferative Neoplasms18 Chronic Lymphocytic Leukemia and Other Mature B- and T/Nk-Cell Leukemias19 Small B-Cell Lymphomas20 Aggressive Mature B-Cell Neoplasms21 Myeloma and Related Neoplasms22 Peripheral T- and NK-Cell Neoplasms23 Hodgkin Lymphoma24 Histiocytic Disorders25 Stem Cell Transplantation26 Normal Hemostasis, Platelet Production and Function27 Vascular and Platelet Bleeding Disorders28 Inherited and Acquired Coagulation Disorders29 Thrombosis and Antithrombotic Therapy30 Hematologic Aspects of Systemic Diseases31 Parasitic Disorders32 Blood TransfusionAppendix 1 2016 World Health Organization Classification of Lymphoid and Myeloid NeoplasmsIndex xxx

"Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing. The latter is perhaps best realized in the first chapter ‘Molecular Biology of the Cell’, where the text and superb figures merge into a highly readable crash course in molecular biology.....I particularly enjoyed the chapter on myelodysplastic syndromes, where clonal heterogeneity is now did actically illustrated.....There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date. Of note, there is now an eTextbook version of the Atlas.....Whenever there comes a new model of your smartphone, reviews always try to decide whether you should update from your old model. I would say that there is every reason to update your atlas, even if you have the second last edition. In conclusion, should you encounter one of the knowledge hungry students (be they of medical or master of science background) asking you whether haematology is an exciting career path to embark upon, one way to answer the question would be to hand her/him this atlas for half an hour. It is a major accomplishment and an excellent recruiting tool!"- Peter Hokland (British Journal of Haematology)

A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, DSc, FMed Sci, is Emeritus Professor of Haematology at University College, London, UK. Paresh Vyas, FRCP, FRCPath, DPhil, is Professor of Haematology, Director of Oxford Centre for Haematology, Honorary Consultant Haematologist and Group Leader, MRC Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Elías Campo, MD, is Senior Consultant and Research Director, Hospital Clinic of Barcelona, and Professor of Anatomical Pathology at University of Barcelona, Faculty of Medicine, Barcelona, Spain. Torsten Haferlach, MD, MLL Munich Leukemia Laboratory, Munich, Germany. Keith Gomez, MBBS, MRCP, FRCPath, PhD, is Consultant Haematologist at Royal Free London NHS Foundation Trust, UK.

• Preface xxx1 Molecular Biology of the Cell2 Hematopoiesis3 Growth Factor Signaling4 Erythropoiesis and Examination of the Peripheral Blood and Bone Marrow5 Hypochromic Anemias6 The Porphyrias and Iron Overload7 Megaloblastic Anemias8 Hemolytic Anemias9 Genetic Disorders of Hemoglobin10 Benign Disorders of Phagocytes11 Benign Disorders of Lymphocytes and Plasma Cells12 Aplastic and Dyserythropoietic Anemias13 The Hematologic Neoplasms: Laboratory Techniques and Acute Myeloid Leukemia14 Acute Lymphoblastic Leukemia15 Myelodysplastic Syndromes16 Myeloproliferative Neoplasms17 Mastocytosis, Myeloid/Lymphoid Neoplasms with Eosinophilia and Specific Cytogenetic Rearrangements, Myelodysplastic/Myeloproliferative Neoplasms18 Chronic Lymphocytic Leukemia and Other Mature B- and T/Nk-Cell Leukemias19 Small B-Cell Lymphomas20 Aggressive Mature B-Cell Neoplasms21 Myeloma and Related Neoplasms22 Peripheral T- and NK-Cell Neoplasms23 Hodgkin Lymphoma24 Histiocytic Disorders25 Stem Cell Transplantation26 Normal Hemostasis, Platelet Production and Function27 Vascular and Platelet Bleeding Disorders28 Inherited and Acquired Coagulation Disorders29 Thrombosis and Antithrombotic Therapy30 Hematologic Aspects of Systemic Diseases31 Parasitic Disorders32 Blood TransfusionAppendix 1 2016 World Health Organization Classification of Lymphoid and Myeloid NeoplasmsIndex xxx

"Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing. The latter is perhaps best realized in the first chapter ‘Molecular Biology of the Cell’, where the text and superb figures merge into a highly readable crash course in molecular biology.....I particularly enjoyed the chapter on myelodysplastic syndromes, where clonal heterogeneity is now did actically illustrated.....There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date. Of note, there is now an eTextbook version of the Atlas.....Whenever there comes a new model of your smartphone, reviews always try to decide whether you should update from your old model. I would say that there is every reason to update your atlas, even if you have the second last edition. In conclusion, should you encounter one of the knowledge hungry students (be they of medical or master of science background) asking you whether haematology is an exciting career path to embark upon, one way to answer the question would be to hand her/him this atlas for half an hour. It is a major accomplishment and an excellent recruiting tool!"- Peter Hokland (British Journal of Haematology)

A. Victor Hoffbrand, MA, DM, FRCP, FRCPath, DSc, FMed Sci, is Emeritus Professor of Haematology at University College, London, UK. Paresh Vyas, FRCP, FRCPath, DPhil, is Professor of Haematology, Director of Oxford Centre for Haematology, Honorary Consultant Haematologist and Group Leader, MRC Molecular Haematology Unit, Radcliffe Department of Medicine, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. Elías Campo, MD, is Senior Consultant and Research Director, Hospital Clinic of Barcelona, and Professor of Anatomical Pathology at University of Barcelona, Faculty of Medicine, Barcelona, Spain. Torsten Haferlach, MD, MLL Munich Leukemia Laboratory, Munich, Germany. Keith Gomez, MBBS, MRCP, FRCPath, PhD, is Consultant Haematologist at Royal Free London NHS Foundation Trust, UK.

• Preface xxx1 Molecular Biology of the Cell2 Hematopoiesis3 Growth Factor Signaling4 Erythropoiesis and Examination of the Peripheral Blood and Bone Marrow5 Hypochromic Anemias6 The Porphyrias and Iron Overload7 Megaloblastic Anemias8 Hemolytic Anemias9 Genetic Disorders of Hemoglobin10 Benign Disorders of Phagocytes11 Benign Disorders of Lymphocytes and Plasma Cells12 Aplastic and Dyserythropoietic Anemias13 The Hematologic Neoplasms: Laboratory Techniques and Acute Myeloid Leukemia14 Acute Lymphoblastic Leukemia15 Myelodysplastic Syndromes16 Myeloproliferative Neoplasms17 Mastocytosis, Myeloid/Lymphoid Neoplasms with Eosinophilia and Specific Cytogenetic Rearrangements, Myelodysplastic/Myeloproliferative Neoplasms18 Chronic Lymphocytic Leukemia and Other Mature B- and T/Nk-Cell Leukemias19 Small B-Cell Lymphomas20 Aggressive Mature B-Cell Neoplasms21 Myeloma and Related Neoplasms22 Peripheral T- and NK-Cell Neoplasms23 Hodgkin Lymphoma24 Histiocytic Disorders25 Stem Cell Transplantation26 Normal Hemostasis, Platelet Production and Function27 Vascular and Platelet Bleeding Disorders28 Inherited and Acquired Coagulation Disorders29 Thrombosis and Antithrombotic Therapy30 Hematologic Aspects of Systemic Diseases31 Parasitic Disorders32 Blood TransfusionAppendix 1 2016 World Health Organization Classification of Lymphoid and Myeloid NeoplasmsIndex xxx

"Substantially updated and now multi-authored so that all aspects of haematology are equally covered, including the newest developments in molecular biology and genomic sequencing. The latter is perhaps best realized in the first chapter ‘Molecular Biology of the Cell’, where the text and superb figures merge into a highly readable crash course in molecular biology.....I particularly enjoyed the chapter on myelodysplastic syndromes, where clonal heterogeneity is now did actically illustrated.....There is a surplus of invention in communicating complex problems here and an admirable effort to keep the reader totally up-to-date. Of note, there is now an eTextbook version of the Atlas.....Whenever there comes a new model of your smartphone, reviews always try to decide whether you should update from your old model. I would say that there is every reason to update your atlas, even if you have the second last edition. In conclusion, should you encounter one of the knowledge hungry students (be they of medical or master of science background) asking you whether haematology is an exciting career path to embark upon, one way to answer the question would be to hand her/him this atlas for half an hour. It is a major accomplishment and an excellent recruiting tool!"- Peter Hokland (British Journal of Haematology)