Coenzyme B12 Enzymes Part A

I am currently Professor of Chemistry and Biological Chemistry at the University of Michigan in Ann Arbor. My research interests center on enzyme mechanisms and protein structure and design. We are currently working on a variety of research projects. In particular, we have a long-standing interest in enzymes that use free radicals to catalyze a variety of unusual chemical transformations. More recently, we have become interested in enzymes involved in hydrocarbon biosynthesis, many of which have novel mechanisms and are of practical interest for the biosynthesis of next-generation biofuels. We are also interested in understanding in molecular detail how enzymes interact with abiological surfaces as this is key to many industrial and biomedical applications where enzymes are immobilized on solid supports. More information about my research can be found here:http://www.lsa.umich.edu/chem/people/faculty/ci.marsheneilg_ci.detail

• 1. B12 Biosynthesis and B12 ChaperonesMartin Warren University of Kent, U.K. 2. Biosynthesis of corrinoidsAmrita Hazra IISER Pune, India3. Guardian of cobamide diversity: probing the role of CobT in lower ligand activation in the biosynthesis of vitamin B12 and other cobamide cofactorsMichiko Taga University of California, Berkeley4. Purification and Detection of Vitamin B12 AnalogsJorge Escalante-Semerena University of Georgia 5. A method for the efficient adenosylation of corrinoidsJorge Escalante-Semerena University of Georgia 6. A method for the production, purification and liposome reconstitution of cobamide synthaseJorge Escalante-Semerena University of Georgia 7. A method for the Isolation of  -ribazole from Vitamin B12, and its Enzymatic Conversion to -ribazole 5’-phosphateRuma Banerjee University of Michigan8. The human B12 trafficking chaperones: CblC, CblD and ATRBernhard Kräutler University of Innsbruck, Austria 9. Synthesis and applications of "antivitamin" B12 derivatives B12-dependent enzyme reactionsTetsuo Toraya Okayama University, Japan10. Coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyaseTetsuo Toraya Okayama University, Japan11. Reactivating chaperones for coenzyme B12-dependent eliminases: Diol and glycerol dehydratases and ethanolamine ammonia-lyaseWolfgang Buckel Marburg University 12. Glutamate mutase and 2-methyleneglutarate mutaseRuma Banerjee University of Michigan13. Human B12 dependent enzymes: Methionine synthase and methylmalonyl-CoA mutaseDavid Leys Manchester University14. Heterologous production and biophysical characterisation of catabolic Nitratireductor pacificus pht-3B reductive dehalogenaseNigel Scrutton Manchester University15. An unusual light-sensing function for coenzyme B12 in bacterial transcription regulator CarH