Capillary Electrophoresis of Carbohydrates
Pierre Thibault, Susumu Honda, Pierre Thibault, Susumu Honda
Inbunden
1 409 kr
Del i serien Methods in Molecular Biology
Capillary Electrophoresis of Carbohydrates
Häftad, Engelska, 2010
1 409 kr
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Glycoconjugates such as glycoproteins and glycolipids play important roles in cell-cell interaction events, including development, differentiation, m- phogenesis, fertilization, inflammation, and metastasis. A number of reports have documented the association of unique oligosaccharide sequences to p- tein targeting and folding, and in mechanisms of infection, inflammation, and immunity. For glycoproteins, these glycan appendages are the result of extensive co- or post-translational modifications of the nascent proteins in the endoplasmic reticulum and in the Golgi apparatus. Although nucleic acids and proteins are copied from a template in a repeated series of identical steps using the same enzymes, complex carbohydrates are formed by the sequential actions of cellular glycosyltransferases that specifically recognize unique s- strates. The molecular biology of these transferases and other carbohydra- modifying enzymes is providing important insights on oligosaccharide recognition events.While it is acknowledged that the definition of the protein complement of cells and tissues (the so-called proteome) remains an enormous task in this postgenomic era, the characterization of all glycans produced by individual organisms (referred to as the glycome) presents an equally imp- tant challenge. This task is further complicated by the fact that oligosacc- rides cannot presently be cloned. These complex carbohydrates exist in a staggering diversity of structures, linkages, and branching, thus providing an exquisite molecular repertoire for cellular interactions.
Produktinformation
- Utgivningsdatum2010-11-10
- Mått152 x 229 x 19 mm
- Vikt490 g
- FormatHäftad
- SpråkEngelska
- SerieMethods in Molecular Biology
- Antal sidor318
- FörlagHumana Press Inc.
- ISBN9781617372063