Cancer Stem Cells

William L. Farrar, PhD, is Head of the Cancer Stem Cell Section at the Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland.

• Preface William L. Farrar; 1. Purification and characterization of cancer stem cells Elaine M. Hurt and William L. Farrar; 2. Prostate cancer stem cells Collene R. Jeter and Dean G. Tang; 3. Melanoma cancer stem cells Alexander Roesch and Meenhard Herlyn; 4. Mammospheres and breast carcinoma Massimiliano Bonafe; 5. Preventative and therapeutic strategies for cancer stem cells Stewart Sell and Gennadi Glinsky; 6. Targeting AML stem cells Monica L. Guzman, Gerrit J. Schuurhuis, and Craig T. Jordan; 7. Plasticity of multi-potent tumor cells and ES cells Lynne-Marie Postovit, Naira V. Margaryan, Elisabeth A. Seftor, Luigi Strizzi, Richard E. B. Seftor, and Mary J. C. Hendrix; 8. Hedgehog and GLI signaling in cancer Fritz Aberger; 9. Targeting notch signaling pathway in cancer stem cells Joon T. Park, Ie-Ming Shih, and Tian-Li Wang; 10. WNT-Beta catenin signaling in cancer Stephen Byers, Michael Pishvaian, Lopa Mishra, and Robert Glazer.

"A succinct analysis of the concept of cancer stem cells (CSCs) in the context of basic and clinical science. The book describes important areas of cancer stem cell research including such topics as isolation and purification of CSCs, signaling pathways involved during self renewal, and pluripotency of these cells, as well as molecular approaches that may be employed to potentially target these pathways....Well written and describes in a general fashion the concepts necessary for basic comprehension of the biology and clinical relevancy of CSCs research. Most of the color illustrations are clear and useful in summarizing the important aspects of CSC research discussed in the text." --Doody's Review Service