Cancer Stem Cells

Dr. Huiping Liu is an expert in breast cancer stem cells and metastasis. She is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Justin Lathia. Dr. Liu’s research recently has been focused on thoroughly understanding the role of microRNAs in breast cancer stem cells, metastasis, and therapy resistance. The goals of the Liu laboratory are to control metastasis and eliminate the mortality associated with breast cancer and other types of cancer. She is known as an active collaborator – bridging research in basic science, engineering, and clinical medicine by engaging physicians and researchers across many institutions. Thus, she is very well known in the field and highly regarded as both a researcher and conference organizer. Dr. Lathia is an expert in brain tumor stem cells. He is co-director of the Cancer Stem Cell Conference in 2014 and 2016 with Huiping Liu. Dr. Lathia’s research has two main areas of focus: using in vivo imaging models to interrogate the tumor microenvironment and examining communication mechanisms used by cancer stem cells to promote their maintenance. His lab is focused on understanding cancer stem cells in real time, so they can be better eliminated by therapy and, thus, prevent tumors from forming, metastasizing, and becoming resistant to therapy.

• Foreword by Jane Visvader and Stanton GersonSection I. CSC Overview and Methodology1. Introduction: Cancer Stem Cells Siddhartha S. Mitra, Joy He, Rogelio Esparza, Gregor Hutter, Samuel H. Cheshier and Irving Weissman2. Overview: Cancer Stem Cell Self-RenewalMaider Zabala, Neethan A. Lobo, Dalong Qian, Linda J. van Weele, Diane Heiser and Michael F. Clarke3. Enrichment and Interrogation of Cancer Stem CellsAwad Jarrar, Anastasia Chumakova, Masahiro Hitomi, Justin LathiaSection II. CSCs in Representative Organ systems4. Critical Updates to the Leukemia Stem Cell ModelYogen Saunthararajah5. Breast cancer stem cells and the move toward high resolution stem cell systemsBenjamin T. Spike6. Lung Cancer Stem Cells: Drivers of Genetically and Histologically Complex DiseaseChristine M. Fillmore and Carla F. Kim7. Colorectal cancer stem cellsSumaiyah Rehman, Jennifer Haynes, Evelyne Lima-Fernandes, Akshita Puri, Andrew Haller, Cherry Leung, Lauren Agro, Yadong Wang, and Catherine A. O’Brien8. Targeting Bladder Cancer Stem Cells: One-Step Closer To The Clinic?Antonina Kurtova and Keith Syson Chan9. Cancer Stem Cells as New therapeutic Targets for Ovarian CancerYinu Wang, Fang Fang, Salvatore Condello, Daniela Matei and Kenneth P. NephewSection III. CSC Features and Mechanisms10. Understanding Cancer Cells of Origin in Cutaneous TumorsHyeongsun Moon, Leanne R. Donahue, Andrew C. White11. Asymmetric Division of Cancer Stem CellsClaudia Petritsch and Xiling Shen12. Metastasis and Metastatic Cells: A Historical Perspective and Current Analysis Kiera Rycaj and Dean G. Tang13. Metastasis and Evasion from the Host Immune ResponsesAvijeet Chopra, Xia Liu, Huiping Liu14. Cancer Stem Cells and Tumor Associated MacrophagesWenchao Zhou and Shideng Bao15. The Mechanisms of Therapy Resistance in Cancer Stem CellsChi-Hsuan Chang and Jeffrey M. Rosen16. Adipose tissue-derived stem cells in regenerative medicine and impact on cancerPraveena S. Thiagarajan, Justin D. Lathia, and Ofer ReizesSection IV. Clinical Applications17. From Research to the Clinic: Targeting Stem Cell Pathways in CancerAustin Gurney and Timothy Hoey18. Targeted Therapies for Glioma Stem CellsSwetha J. Sundar, James Wright, Jason K. Hseih & Andrew E. Sloan19. Circulating tumor cells, cancer stem cells, and emerging microfluidic detection technologies with clinical applicationsMolly Kozminsky and Sunitha Nagrath