Howard Fillit, MD, is a geriatrician, neuroscientist, and innovative philanthropy executive, who has held faculty positions at The Rockefeller University, the SUNY-Stony Brook School of Medicine and the Cornell University School of Medicine. In 1987, he joined the Mount Sinai School of Medicine, where he is a clinical professor of geriatric medicine and palliative care, medicine and neuroscience. He has authored or co-authored more than 300 publications and is the senior editor of Brocklehurst's Textbook of Geriatric Medicine and Gerontology. Dr. Fillit is the recipient of many awards and honors including the Rita Hayworth Award from the Alzheimer's Association. He is a fellow of the American Geriatrics Society, the American College of Physicians, the Gerontological Society of America and the New York Academy of Medicine. Dr. Fillit earned his bachelor of arts in neurobiology cum laude from Cornell University and his medical degree from the SUNY-Upstate Medical University. Dr. Kenneth Rockwood is a professor of medicine (geriatric medicine and community health & epidemiology) at Dalhousie, a Canadian Institutes of Health Research investigator and an active staff physician. He is also the Kathryn Allen Weldon Professor of Alzheimer Research at Dalhousie University. A native of Newfoundland, he received his MD from Memorial University, and completed internal medicine training at the University of Alberta and geriatric medicine at Dalhousie University. A leading authority on frailty, Dr. Rockwood has more than 400 peer-reviewed publications and nine books to his credit, including the eighth edition of the Brocklehurst's Textbook of Geriatric Medicine & Gerontology. He is a member of the executive committee of the Canadian Collaboration on Neurodegeneration in Aging, and leads its Quality of Life theme, and The Knowledge Translation platform.

• PART I GerontologySECTION A Introduction to Gerontology1 Introduction: Aging, Frailty, and Geriatric Medicine2 The Epidemiology of Aging3 The Future of Old Age4 Successful Aging: The CentenariansSECTION B Biological Gerontology5 Evolution Theory and the Mechanisms of Aging6 Methodological Challenges of Research in Older People7 Geroscience8 Genetic Mechanisms on Aging9 Cellular Mechanisms of Aging10 The Premature Aging Syndrome: Hutchison-Gilford Progeria Syndrome - Insights Into Normal Aging11 The Neurobiology of Aging: Free Radical Stress and Metabolic Pathways12 Allostasis and Allostatic Overload in the Context of Aging13 Neuroendocrinology of AgingSECTION C Medical Gerontology14 Frailty: The Broad View15 Aging and Deficit Accumulation: Clinical Implications16 Effects of Aging on the Cardiovascular System17 Age-Related Changes in the Respiratory System18 Neurologic Signs in Older Adults19 Connective Tissues and Aging20 Bone and Joint Aging21 Aging and the Gastrointestinal System22 Aging of the Urinary Tract23 Endocrinology of Aging24 Aging and the Blood25 Aging and the Skin26 The Pharmacology of Aging27 Anti-Aging InterventionsSECTION D Psychological and Social Gerontology28 Normal Cognitive Aging29 Social Gerontology30 Social Vulnerability in Old Age31 The Aging Personality and Self: Diversity and Health Issues32 Productive AgingPART II Geriatric MedicineSECTION A Evaluation of the Geriatric Patient33 Presentation of Disease in Old Age34 Multidimensional Geriatric Assessment35 Laboratory Diagnosis and Geriatrics: More Than Just Reference Intervals for Older Adults36 Social Assessment of Older Patients37 Surgery and Anesthesia in the Frail Older Patient38 Measuring Outcomes of Multidimensional Geriatric Assessment ProgramsSECTION B Cardiovascular System39 Chronic Cardiac Failure40 Diagnosis and Management of Coronary Artery Disease41 Practical Issues in the Care of Frail Older Cardiac Patients42 Hypertension43 Valvular Heart Disease44 Cardiac Arrhythmias45 Syncope46 Vascular Surgery47 Venous Thromboembolism in Older AdultsSECTION C The Respiratory System48 Asthma and Chronic Obstructive Pulmonary Disease49 Nonobstructive Lung Disease And Thoracic TumoursSECTION D The Nervous System50 Classification of the Dementias51 Neuropsychology in the Diagnosis and Treatment of Dementia52 Alzheimer's Disease53 Vascular Cognitive Disorders54 Frontotemporal Lobar Degeneration55 Delirium56 Mental Illness in Older Adults57 Intellectual Disability in Older Adults58 Epilepsy59 Headache And Facial Pain60 Stroke: Epidemiology and Pathology61 Stroke: Clinical Presentation, Management and Organization of Services62 Long-Term Stroke Care63 Disorders of The Autonomic Nervous System64 Parkinsonism and Other Movement Disorders65 Neuromuscular Disorders66 Intracranial Tumors67 Disorders of The Spinal Cord and Nerve Roots68 Central Nervous System InfectionsSECTION E Musculoskeletal System69 Arthritis in Older Adults70 Metabolic Bone Disease71 Orthopedic Geriatrics72 SarcopeniaSECTION F Gastroenterology73 The Pancreas74 The Liver75 Biliary Tract Diseases76 The Upper Gastrointestinal Tract77 The Small Bowel78 The Large Bowel79 Nutrition and Aging80 ObesitySECTION G Genitourinary Tract81 Diseases of the Aging Kidney82 Disorders of Water and Electrolyte Metabolism83 The Prostate84 Aging Males and TestosteroneSECTION H Women’s Health85 Gynecological Disorders in Older Women86 Breast CancerSECTION I Endocrinoloy87 Adrenal and Pituitary Disorders88 Disorders of the Thyroid89 Disorders of the Parathyroid Glands90 Diabetes MellitusSECTION J Hematology and Oncology91 Blood Disorders in Older Adults92 Geriatric Oncology93 Clinical Immunology: Immune Senescence and the Acquired Immunodeficiency of AgingSECTION K Skin and Special Senses94 Skin Diseases and Old Age95 Aging and Disorders of the Eye96 Disorders of HearingPART IIISECTION A Prevention and Health Promotion97 Health Promotion for Community-Living Older Adults98 Sexuality in Old Age99 Physical Activity for Successful Aging100 Rehabilitation: Evidence-Based Physical and Occupational Therapy Techniques for Stroke and Parkinson DiseaseSECTION B Geriatric Syndromes and Other Unique Problems of the Geriatric Patient101 Geriatric Pharmacotherapy and Polypharmacy102 Impaired Mobility103 Falls104 Podiatry105 Constipation and Fecal Incontinence in Old Age106 Urinary Incontinence107 Pressure Ulcers108 Sleep in Relation to Aging, Frailty, and Cognition109 Malnutrition in Older Adults110 Geriatric Dentistry: Maintaining Oral Health in the Geriatric Population111 Pain in Old Age112 The Mistreatment and Neglect of Frail Older People113 HIV & Aging: Current Status and Evolving Perspectives114 Palliative Care115 Ethical Issues in Geriatric MedicinePART IVHealth Systems and Geriatric Medicine116 Managing Frailty: Roles for Primary Care117 Geriatric Emergency and Prehospital Care118 Acute Hospital Care for Frail Older Adults119 Intensive Care Medicine in Older Adults: A Critical Age?120 Geriatrics in Europe121 Geriatrics in North America122 Geriatrics in Asia123 Geriatrics in Latin America124 Medical Care for Older Long-Term Care Residents in the United Kingdom125 Institutional Long-Term Care Services in the United States126 Education in Geriatric Medicine127 Improving Quality of Care for Older People in England128 Quality Initiatives Aimed at Improving Medicare129 Managed Care for Older Americans130 Telemedicine Applications in Geriatrics131 Gerontechnology132 Optimizing the Built Environment for Frail Older Adults133 Transcultural Geriatrics

"...it would make an excellent addition to any nursing library or resource for a ward or community team."The study of elderly medicine impacts on a large number of disciplines and of course it is a speciality in its own right. So it is very useful to have access to a good textbook to help a user explore this subject and act as a good reference source. So does this book fit the bill? Well the answer is a definite yes as it is an excellent all round textbook." -Dr. Harry Brown (August 2016, www.glycosmedia.com)

Howard Fillit, MD, is a geriatrician, neuroscientist, and innovative philanthropy executive, who has held faculty positions at The Rockefeller University, the SUNY-Stony Brook School of Medicine and the Cornell University School of Medicine. In 1987, he joined the Mount Sinai School of Medicine, where he is a clinical professor of geriatric medicine and palliative care, medicine and neuroscience. He has authored or co-authored more than 300 publications and is the senior editor of Brocklehurst's Textbook of Geriatric Medicine and Gerontology. Dr. Fillit is the recipient of many awards and honors including the Rita Hayworth Award from the Alzheimer's Association. He is a fellow of the American Geriatrics Society, the American College of Physicians, the Gerontological Society of America and the New York Academy of Medicine. Dr. Fillit earned his bachelor of arts in neurobiology cum laude from Cornell University and his medical degree from the SUNY-Upstate Medical University. Dr. Kenneth Rockwood is a professor of medicine (geriatric medicine and community health & epidemiology) at Dalhousie, a Canadian Institutes of Health Research investigator and an active staff physician. He is also the Kathryn Allen Weldon Professor of Alzheimer Research at Dalhousie University. A native of Newfoundland, he received his MD from Memorial University, and completed internal medicine training at the University of Alberta and geriatric medicine at Dalhousie University. A leading authority on frailty, Dr. Rockwood has more than 400 peer-reviewed publications and nine books to his credit, including the eighth edition of the Brocklehurst's Textbook of Geriatric Medicine & Gerontology. He is a member of the executive committee of the Canadian Collaboration on Neurodegeneration in Aging, and leads its Quality of Life theme, and The Knowledge Translation platform.

• PART I GerontologySECTION A Introduction to Gerontology1 Introduction: Aging, Frailty, and Geriatric Medicine2 The Epidemiology of Aging3 The Future of Old Age4 Successful Aging: The CentenariansSECTION B Biological Gerontology5 Evolution Theory and the Mechanisms of Aging6 Methodological Challenges of Research in Older People7 Geroscience8 Genetic Mechanisms on Aging9 Cellular Mechanisms of Aging10 The Premature Aging Syndrome: Hutchison-Gilford Progeria Syndrome - Insights Into Normal Aging11 The Neurobiology of Aging: Free Radical Stress and Metabolic Pathways12 Allostasis and Allostatic Overload in the Context of Aging13 Neuroendocrinology of AgingSECTION C Medical Gerontology14 Frailty: The Broad View15 Aging and Deficit Accumulation: Clinical Implications16 Effects of Aging on the Cardiovascular System17 Age-Related Changes in the Respiratory System18 Neurologic Signs in Older Adults19 Connective Tissues and Aging20 Bone and Joint Aging21 Aging and the Gastrointestinal System22 Aging of the Urinary Tract23 Endocrinology of Aging24 Aging and the Blood25 Aging and the Skin26 The Pharmacology of Aging27 Anti-Aging InterventionsSECTION D Psychological and Social Gerontology28 Normal Cognitive Aging29 Social Gerontology30 Social Vulnerability in Old Age31 The Aging Personality and Self: Diversity and Health Issues32 Productive AgingPART II Geriatric MedicineSECTION A Evaluation of the Geriatric Patient33 Presentation of Disease in Old Age34 Multidimensional Geriatric Assessment35 Laboratory Diagnosis and Geriatrics: More Than Just Reference Intervals for Older Adults36 Social Assessment of Older Patients37 Surgery and Anesthesia in the Frail Older Patient38 Measuring Outcomes of Multidimensional Geriatric Assessment ProgramsSECTION B Cardiovascular System39 Chronic Cardiac Failure40 Diagnosis and Management of Coronary Artery Disease41 Practical Issues in the Care of Frail Older Cardiac Patients42 Hypertension43 Valvular Heart Disease44 Cardiac Arrhythmias45 Syncope46 Vascular Surgery47 Venous Thromboembolism in Older AdultsSECTION C The Respiratory System48 Asthma and Chronic Obstructive Pulmonary Disease49 Nonobstructive Lung Disease And Thoracic TumoursSECTION D The Nervous System50 Classification of the Dementias51 Neuropsychology in the Diagnosis and Treatment of Dementia52 Alzheimer's Disease53 Vascular Cognitive Disorders54 Frontotemporal Lobar Degeneration55 Delirium56 Mental Illness in Older Adults57 Intellectual Disability in Older Adults58 Epilepsy59 Headache And Facial Pain60 Stroke: Epidemiology and Pathology61 Stroke: Clinical Presentation, Management and Organization of Services62 Long-Term Stroke Care63 Disorders of The Autonomic Nervous System64 Parkinsonism and Other Movement Disorders65 Neuromuscular Disorders66 Intracranial Tumors67 Disorders of The Spinal Cord and Nerve Roots68 Central Nervous System InfectionsSECTION E Musculoskeletal System69 Arthritis in Older Adults70 Metabolic Bone Disease71 Orthopedic Geriatrics72 SarcopeniaSECTION F Gastroenterology73 The Pancreas74 The Liver75 Biliary Tract Diseases76 The Upper Gastrointestinal Tract77 The Small Bowel78 The Large Bowel79 Nutrition and Aging80 ObesitySECTION G Genitourinary Tract81 Diseases of the Aging Kidney82 Disorders of Water and Electrolyte Metabolism83 The Prostate84 Aging Males and TestosteroneSECTION H Women’s Health85 Gynecological Disorders in Older Women86 Breast CancerSECTION I Endocrinoloy87 Adrenal and Pituitary Disorders88 Disorders of the Thyroid89 Disorders of the Parathyroid Glands90 Diabetes MellitusSECTION J Hematology and Oncology91 Blood Disorders in Older Adults92 Geriatric Oncology93 Clinical Immunology: Immune Senescence and the Acquired Immunodeficiency of AgingSECTION K Skin and Special Senses94 Skin Diseases and Old Age95 Aging and Disorders of the Eye96 Disorders of HearingPART IIISECTION A Prevention and Health Promotion97 Health Promotion for Community-Living Older Adults98 Sexuality in Old Age99 Physical Activity for Successful Aging100 Rehabilitation: Evidence-Based Physical and Occupational Therapy Techniques for Stroke and Parkinson DiseaseSECTION B Geriatric Syndromes and Other Unique Problems of the Geriatric Patient101 Geriatric Pharmacotherapy and Polypharmacy102 Impaired Mobility103 Falls104 Podiatry105 Constipation and Fecal Incontinence in Old Age106 Urinary Incontinence107 Pressure Ulcers108 Sleep in Relation to Aging, Frailty, and Cognition109 Malnutrition in Older Adults110 Geriatric Dentistry: Maintaining Oral Health in the Geriatric Population111 Pain in Old Age112 The Mistreatment and Neglect of Frail Older People113 HIV & Aging: Current Status and Evolving Perspectives114 Palliative Care115 Ethical Issues in Geriatric MedicinePART IVHealth Systems and Geriatric Medicine116 Managing Frailty: Roles for Primary Care117 Geriatric Emergency and Prehospital Care118 Acute Hospital Care for Frail Older Adults119 Intensive Care Medicine in Older Adults: A Critical Age?120 Geriatrics in Europe121 Geriatrics in North America122 Geriatrics in Asia123 Geriatrics in Latin America124 Medical Care for Older Long-Term Care Residents in the United Kingdom125 Institutional Long-Term Care Services in the United States126 Education in Geriatric Medicine127 Improving Quality of Care for Older People in England128 Quality Initiatives Aimed at Improving Medicare129 Managed Care for Older Americans130 Telemedicine Applications in Geriatrics131 Gerontechnology132 Optimizing the Built Environment for Frail Older Adults133 Transcultural Geriatrics

"...it would make an excellent addition to any nursing library or resource for a ward or community team."The study of elderly medicine impacts on a large number of disciplines and of course it is a speciality in its own right. So it is very useful to have access to a good textbook to help a user explore this subject and act as a good reference source. So does this book fit the bill? Well the answer is a definite yes as it is an excellent all round textbook." -Dr. Harry Brown (August 2016, www.glycosmedia.com)

Howard Fillit, MD, is a geriatrician, neuroscientist, and innovative philanthropy executive, who has held faculty positions at The Rockefeller University, the SUNY-Stony Brook School of Medicine and the Cornell University School of Medicine. In 1987, he joined the Mount Sinai School of Medicine, where he is a clinical professor of geriatric medicine and palliative care, medicine and neuroscience. He has authored or co-authored more than 300 publications and is the senior editor of Brocklehurst's Textbook of Geriatric Medicine and Gerontology. Dr. Fillit is the recipient of many awards and honors including the Rita Hayworth Award from the Alzheimer's Association. He is a fellow of the American Geriatrics Society, the American College of Physicians, the Gerontological Society of America and the New York Academy of Medicine. Dr. Fillit earned his bachelor of arts in neurobiology cum laude from Cornell University and his medical degree from the SUNY-Upstate Medical University. Dr. Kenneth Rockwood is a professor of medicine (geriatric medicine and community health & epidemiology) at Dalhousie, a Canadian Institutes of Health Research investigator and an active staff physician. He is also the Kathryn Allen Weldon Professor of Alzheimer Research at Dalhousie University. A native of Newfoundland, he received his MD from Memorial University, and completed internal medicine training at the University of Alberta and geriatric medicine at Dalhousie University. A leading authority on frailty, Dr. Rockwood has more than 400 peer-reviewed publications and nine books to his credit, including the eighth edition of the Brocklehurst's Textbook of Geriatric Medicine & Gerontology. He is a member of the executive committee of the Canadian Collaboration on Neurodegeneration in Aging, and leads its Quality of Life theme, and The Knowledge Translation platform.

• PART I GerontologySECTION A Introduction to Gerontology1 Introduction: Aging, Frailty, and Geriatric Medicine2 The Epidemiology of Aging3 The Future of Old Age4 Successful Aging: The CentenariansSECTION B Biological Gerontology5 Evolution Theory and the Mechanisms of Aging6 Methodological Challenges of Research in Older People7 Geroscience8 Genetic Mechanisms on Aging9 Cellular Mechanisms of Aging10 The Premature Aging Syndrome: Hutchison-Gilford Progeria Syndrome - Insights Into Normal Aging11 The Neurobiology of Aging: Free Radical Stress and Metabolic Pathways12 Allostasis and Allostatic Overload in the Context of Aging13 Neuroendocrinology of AgingSECTION C Medical Gerontology14 Frailty: The Broad View15 Aging and Deficit Accumulation: Clinical Implications16 Effects of Aging on the Cardiovascular System17 Age-Related Changes in the Respiratory System18 Neurologic Signs in Older Adults19 Connective Tissues and Aging20 Bone and Joint Aging21 Aging and the Gastrointestinal System22 Aging of the Urinary Tract23 Endocrinology of Aging24 Aging and the Blood25 Aging and the Skin26 The Pharmacology of Aging27 Anti-Aging InterventionsSECTION D Psychological and Social Gerontology28 Normal Cognitive Aging29 Social Gerontology30 Social Vulnerability in Old Age31 The Aging Personality and Self: Diversity and Health Issues32 Productive AgingPART II Geriatric MedicineSECTION A Evaluation of the Geriatric Patient33 Presentation of Disease in Old Age34 Multidimensional Geriatric Assessment35 Laboratory Diagnosis and Geriatrics: More Than Just Reference Intervals for Older Adults36 Social Assessment of Older Patients37 Surgery and Anesthesia in the Frail Older Patient38 Measuring Outcomes of Multidimensional Geriatric Assessment ProgramsSECTION B Cardiovascular System39 Chronic Cardiac Failure40 Diagnosis and Management of Coronary Artery Disease41 Practical Issues in the Care of Frail Older Cardiac Patients42 Hypertension43 Valvular Heart Disease44 Cardiac Arrhythmias45 Syncope46 Vascular Surgery47 Venous Thromboembolism in Older AdultsSECTION C The Respiratory System48 Asthma and Chronic Obstructive Pulmonary Disease49 Nonobstructive Lung Disease And Thoracic TumoursSECTION D The Nervous System50 Classification of the Dementias51 Neuropsychology in the Diagnosis and Treatment of Dementia52 Alzheimer's Disease53 Vascular Cognitive Disorders54 Frontotemporal Lobar Degeneration55 Delirium56 Mental Illness in Older Adults57 Intellectual Disability in Older Adults58 Epilepsy59 Headache And Facial Pain60 Stroke: Epidemiology and Pathology61 Stroke: Clinical Presentation, Management and Organization of Services62 Long-Term Stroke Care63 Disorders of The Autonomic Nervous System64 Parkinsonism and Other Movement Disorders65 Neuromuscular Disorders66 Intracranial Tumors67 Disorders of The Spinal Cord and Nerve Roots68 Central Nervous System InfectionsSECTION E Musculoskeletal System69 Arthritis in Older Adults70 Metabolic Bone Disease71 Orthopedic Geriatrics72 SarcopeniaSECTION F Gastroenterology73 The Pancreas74 The Liver75 Biliary Tract Diseases76 The Upper Gastrointestinal Tract77 The Small Bowel78 The Large Bowel79 Nutrition and Aging80 ObesitySECTION G Genitourinary Tract81 Diseases of the Aging Kidney82 Disorders of Water and Electrolyte Metabolism83 The Prostate84 Aging Males and TestosteroneSECTION H Women’s Health85 Gynecological Disorders in Older Women86 Breast CancerSECTION I Endocrinoloy87 Adrenal and Pituitary Disorders88 Disorders of the Thyroid89 Disorders of the Parathyroid Glands90 Diabetes MellitusSECTION J Hematology and Oncology91 Blood Disorders in Older Adults92 Geriatric Oncology93 Clinical Immunology: Immune Senescence and the Acquired Immunodeficiency of AgingSECTION K Skin and Special Senses94 Skin Diseases and Old Age95 Aging and Disorders of the Eye96 Disorders of HearingPART IIISECTION A Prevention and Health Promotion97 Health Promotion for Community-Living Older Adults98 Sexuality in Old Age99 Physical Activity for Successful Aging100 Rehabilitation: Evidence-Based Physical and Occupational Therapy Techniques for Stroke and Parkinson DiseaseSECTION B Geriatric Syndromes and Other Unique Problems of the Geriatric Patient101 Geriatric Pharmacotherapy and Polypharmacy102 Impaired Mobility103 Falls104 Podiatry105 Constipation and Fecal Incontinence in Old Age106 Urinary Incontinence107 Pressure Ulcers108 Sleep in Relation to Aging, Frailty, and Cognition109 Malnutrition in Older Adults110 Geriatric Dentistry: Maintaining Oral Health in the Geriatric Population111 Pain in Old Age112 The Mistreatment and Neglect of Frail Older People113 HIV & Aging: Current Status and Evolving Perspectives114 Palliative Care115 Ethical Issues in Geriatric MedicinePART IVHealth Systems and Geriatric Medicine116 Managing Frailty: Roles for Primary Care117 Geriatric Emergency and Prehospital Care118 Acute Hospital Care for Frail Older Adults119 Intensive Care Medicine in Older Adults: A Critical Age?120 Geriatrics in Europe121 Geriatrics in North America122 Geriatrics in Asia123 Geriatrics in Latin America124 Medical Care for Older Long-Term Care Residents in the United Kingdom125 Institutional Long-Term Care Services in the United States126 Education in Geriatric Medicine127 Improving Quality of Care for Older People in England128 Quality Initiatives Aimed at Improving Medicare129 Managed Care for Older Americans130 Telemedicine Applications in Geriatrics131 Gerontechnology132 Optimizing the Built Environment for Frail Older Adults133 Transcultural Geriatrics

"...it would make an excellent addition to any nursing library or resource for a ward or community team."The study of elderly medicine impacts on a large number of disciplines and of course it is a speciality in its own right. So it is very useful to have access to a good textbook to help a user explore this subject and act as a good reference source. So does this book fit the bill? Well the answer is a definite yes as it is an excellent all round textbook." -Dr. Harry Brown (August 2016, www.glycosmedia.com)