Dr. Kenneth Rockwood is a professor of medicine (geriatric medicine and community health & epidemiology) at Dalhousie, a Canadian Institutes of Health Research investigator and an active staff physician. He is also the Kathryn Allen Weldon Professor of Alzheimer Research at Dalhousie University. A native of Newfoundland, he received his MD from Memorial University, and completed internal medicine training at the University of Alberta and geriatric medicine at Dalhousie University. A leading authority on frailty, Dr. Rockwood has more than 400 peer-reviewed publications and nine books to his credit, including the eighth edition of the Brocklehurst's Textbook of Geriatric Medicine & Gerontology. He is a member of the executive committee of the Canadian Collaboration on Neurodegeneration in Aging, and leads its Quality of Life theme, and The Knowledge Translation platform.Professor Ruth E. Hubbard qualified from St. Mary's Hospital, London and trained in Cardiff, Wales, completing an MSc in Medical Education and an MD on frailty pathophysiology before undertaking a post-doctoral fellowship in Dalhousie University, Nova Scotia. She is now the leading frailty expert in Australia, with dual clinical and research leadership roles. As the Director of General and Geriatric Medicine & Consultant Geriatrician at the Princess Alexandra Hospital in Brisbane, Queensland, she has led the establishment of frailty-focused models of care including a peri-operative geriatric medicine service, geriatrician-led care in the Emergency Department and specialised dementia care wards for people with challenging behaviours. As Masonic Chair of Geriatric Medicine at The University of Queensland, she created the Australian Frailty Network, a national partnership of researchers, clinicians, professional associations and consumers, with the vision of delivering a national response to frailty that enables frailty-informed care for all older Australians.She has generated $43mill funding, more than 200 publications, 100 conference appearances, eight book chapters and Consensus Statements supporting national and international policy.Andrew P. Clegg is Professor and Chair of Geriatric Medicine, University of Leeds, Honorary Consultant Geriatrician, Bradford Royal Infirmary.

• PART I: GerontologySection A: Introduction to Gerontology1. Introduction to Aging, Frailty and Geriatric Medicine2. The Epidemiology of Aging3. Successful Aging: The CentenariansSection B: Biological Gerontology4. Evolution Theory and the Mechanisms of Aging5. Sex Differences in Aging6. Geroscience7. Genetics and Epigenetics8. Oxidative Damage and Free Radical Stress9. Inflammation10. Cellular Senescence11. The Microbiome12. The Premature Aging Syndrome: Hutchinson-Gilford Progeria Syndrome: Insights Into Normal Aging13. Interventions for Lifespan ExtensionSection C: Medical Gerontology14. Frailty: The Broad View15. Aging and Deficit Accumulation: Clinical Implications16. Effects of Age and Frailty on the Cardiovascular System17. Age-Related Changes in the Respiratory System18. The Aging Immune System and the Aging Brain19. Neurologic Signs in Older Adults20. Connective Tissues and Aging21. Bone and Joint Aging22. Age-Related Changes in the Gastrointestinal System23. Aging of the Urinary Tract24. Endocrinology of Aging25. Aging and the Skin26. The Pharmacology of Aging27. Antiaging MedicineSection D: Psychological and Social Gerontology28. Normal Cognitive Aging and Maintenance29. Social Gerontology30. Social Vulnerability in Old Age31. The Aging Self32. Aging among LGBTQ+ Populations33. Optimising the Longevity DividendPART II: Geriatric MedicineSection A: Evaluation of the Geriatric Patient34. Presentation of Disease in Old Age35. Comprehensive Geriatric Assessment36. Laboratory Diagnosis and Geriatrics: More Than Just Reference Intervals for Older Adults37. Perioperative Medicine in the Frail Older Patient38. Solid Organ Transplantation in the Older Adult39. Measuring Outcomes of Multidimensional Geriatric Assessment ProgramsSection B: Cardiovascular System40. Chronic Cardiac Failure in Older Adults41. Diagnosis and Management of Coronary Artery Disease in Older Adults42. Practical Issues in the Care of Frail Older Cardiac Patients43. Hypertension in Older Adults44. Valvular Heart Disease in Older Adults45. Common Arrhythmias and Conduction Diseases in Older Adults46. Syncope in Older Adults47. Vascular Surgery in Older AdultsSection C: The Respiratory System48. COVID-19 in Older Adults49. Asthma and Chronic Obstructive Pulmonary Disease in Older Adults50. Nonobstructive Lung Disease in Older AdultsSection D: The Nervous System51. Neuropsychological Evaluation in the Diagnosis and Treatment of Dementia in Frail Elders52. Alzheimer's Disease and Late Life Dementia53. Vascular Cognitive Disorders54. Frontotemporal Dementia Spectrum Disorders55. Mental Illness in Older Adults56. Intellectual Disability in Older Adults57. Epilepsy in Older Adults58. Headache and Facial Pain in Older Adults59. Stroke: Epidemiology and Pathology60. Stroke: Clinical Presentation, Management and Organisation of Services61. Long-Term Stroke Care62. Disorders of the Autonomic Nervous System in Older Adults63. Parkinsonism and Other Movement Disorders64. Neuromuscular Disorders in Older Adults65. Disorders of the Spinal Cord and Nerve Roots in Older AdultsSection E: Musculoskeletal System66. Arthritis in Older Adults67. Metabolic Bone Disease in Older Adults68. Orthopedic Geriatrics69. SarcopeniaSection F: Gastroenterology70. Diseases of the Biliary Tract and the Pancreas in Older Adults71. The Liver and the Older Adult72. The Upper Gastrointestinal Tract and the Older Adult73. The Small and the Large Bowel and the Older AdultSection G: Genitourinary Tract74. The Aging Kidney75. The Prostate and the Older Adult76. Testosterone and Frailty in Aging MalesSection H: Women's Health77. Gynecologic Disorders in Older Women78. Health and Wellbeing in Older WomenSection I: Endocrinology79. Adrenal and Pituitary Disorders80. Disorders of the Thyroid and the Parathyroid Glands in the Older Adult81. Diabetes Mellitus in the Older AdultSection J: Immunology and Hematology82. Clinical Immunology: Changes to Immunity with Age and Clinical Consequences for Older Adults83. Vaccination in Older Adults84. HIV and Aging: Current Status and Evolving Perspectives85. Blood Disorders in Older Adults86. Venous Thromboembolism in Older AdultsSection K: Oncology87. Geriatric Oncology88. Cancer Genomics89. Chemotherapy in Older Adults90. Radiotherapy in Older Adults91. Immunotherapy in Older Adults92. Supportive and Palliative Care in Cancer93. Colorectal Cancer in Older Adults94. Prostate Cancer in Older Adults95. Lung Cancer in Older Adults96. Haematological Cancer in Older Adults97. Breast Cancer in Older Adults98. Gynaecological Cancer in Older Adults99. Upper Gastrointestinal Cancer in Older Adults100. Skin Cancer in Older Adults101. Neurological Cancer in Older Adults102. Thyroid Cancer in Older AdultsSection L: Skin and Special Senses103. Benign Skin Lesions in Older Adults104. Inflammatory Skin Disorders in Older Adults105. Vision and Hearing in Older AdultsPART III: Problem-Based Geriatric MedicineSection A: Prevention and Health Promotion106. Health Promotion for Community-Living Older Adults107. Sexuality in Old Age108. Physical Activity for Healthy Aging109. Optimization of Nutrition110. Rehabilitation: Evidence-Based Physical and Occupational Therapy Techniques for Stroke and Parkinson DiseaseSection B: Geriatric Syndromes and Other Unique Problems of the Geriatric Patient111. Delirium112. Falls113. Functional Decline114. Urinary Incontinence115. Malnutrition in Older Adults116. Oropharyngeal Swallowing Problems in Older AdultsSection C: Common Problems of the Older Person117. Optimization of Medicines for Older People118. Impaired Balance and Mobility in Older Adults119. Dentistry in Older People: Maintaining Oral Health in Aging and Frailty120. Foot problems in older people121. Obesity and Sarcopenic Obesity122. Constipation and Fecal Incontinence in Old Age123. Pressure Injuries in Older Adults124. Sleep in Relation to Aging, Frailty, and Cognition125. Pain in the Older AdultSection D: Challening Management Problems126. The Mistreatment and Neglect of Frail Older Adults127. Non-Cancer Palliative Medicine for Older Adults128. Ethical Issues in Geriatric MedicinePART IV: Health Systems and Geriatric Medicine129. Managing Frailty: Roles for Primary Care130. Geriatric Emergency Medicine131. Acute Hospital Care for Frail Older Adults132. Intensive Care Medicine in Older Adults: A Critical Age?133. System-wide Reform for Frailty Care134. Geriatric Medicine in Europe135. Geriatric Medicine in Canada and the United States136. Aging and Geriatric Medicine in the Asia Pacific Region137. Geriatric Medicine in Africa138. Geriatrics in Latin America139. Aging Among Indigenous Communities140. Medical Care for Older Long-Term Care Residents in the United Kingdom/Other141. Institutional Long-Term Care in the United States142. Education in Geriatric Medicine143. Improving Quality of Care for Older Adults144. Managed Care for Older Americans145. Telemedicine Applications in Geriatrics146. Technology for Older Adults147. Optimizing the Built Environment for Frail Older Adults148. Transcultulral Geriatrics149. Intergenerational Resilience - Social Gerontology150. Controversies in Geriatric Medicine

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