Bioactive Compounds

Prof. Dr. Cristobal N. Aguilar, Chemist, PhD, was the Director of the Research and Postgraduate Programs at Autonomous University of Coahuila (2018–2024, Mexico, where from 2014 to 2018, he was the Dean of the School of Chemistry. He is a Level III member of S.N.I. (Mexican System of Researchers). He has received several prizes and awards, among which the most important are the National Prize of Research 2010 of the Mexican Academy of Sciences, the Prize “Carlos Casas Campillo 2008” of the Mexican Society of Biotechnology and Bioengineering, the National Prize AgroBio–2005, the Mexican Prize in Food Science and Technology from CONACYT-Coca Cola México 2003, the 2018 Outstanding Researcher Award by the International Association of Bioprocessing, and the 2019 Coahuila State Innovation Science and Technology Award. He's developed more than 30 research projects, including seven international exchange projects. He is a member of the Mexican Academy of Science (since 2014). Eliseo Cárdenas Hernández is a Pharmaceutical Chemist Biologist from the Autonomous University of Coahuila (UAdeC), Mexico. He obtained his master's degree in Food Science and Technology from UAdeC and a master's degree in Biological Sciences from the Federal University of Pernambuco, Brazil. He is a PhD student at the same program. He is a candidate for State Researcher by COECYT, Mexico and is a member of the Mexican Association of Food Science. He obtained the Lobo Award of Excellence in Academic Activities of the UAdeC in 2021. In addition, due to his master’s studies, he was recognized with the “Juan Antonio de la Fuente” Medal (UAdeC) in 2024.His scientific productivity includes several articles and book chapters. Also, he is a peer reviewer for the international journals Heliyon and Journal of Cleaner Production of Elsevier, and has actively participated in national and international congresses as part of the organizing committee, speaker or assistant. Prof. Dr. Rafael Matos Ximenes is a pharmacist with an MSc and PhD in Pharmacology. He has been a Full-time Professor at the Centre for Biosciences at the Federal University of Pernambuco (UFPE), Brazil, for the past decade. During this time, he also served as a visiting researcher at the University of Nantes, France, and the University of Seville, Spain. At UFPE, he was Chair of the Doctoral School of Biotechnology (2019–2023) and Vice-Chair of the Doctoral School in Pharmaceutical Sciences (2016–2017). As the Principal Investigator of the Research Group on Ethnopharmacology and Phytochemistry, his work focuses on the intersection of food and drugs, particularly exploring bioactive compounds from Amazon and Caatinga biodiversity for the prevention and treatment of immuno-mediated chronic inflammatory diseases. Throughout his career, he has supervised 12 PhD theses and 10 MSc theses and has published more than 65 papers in international indexed journals.Jose Sandoval Cortes is a Chemist, PhD, and full-time Professor at the School of Chemistry, Autonomous University of Coahuila, Mexico, for the last 12 years. He worked in a research stay in electrochemistry at the University of Paris 6 Pierre et Marie Curie, France; the National University of Cordoba, Argentina; and the National University of Rio Cuarto, Argentina. His research work has been published in six papers in indexed journals, three book chapters, and 20 contributions at scientific meetings. Since 2018, he has been part of the administrative staff of the Research and Postgraduate Studies Office at the Autonomous University of Coahuila. He received the Pharmaceutical Chemist Biologist degree in 2001, the MSc degree in chemistry in 2003, and the PhD degree in electrochemistry in 2006 from the University of Guanajuato, Mexico.

• Section 1: Foundations of Bioactive Compounds1. Introduction2. Bioactive Compounds: Sources and Their Benefits to Human Health3. Bioactive Compound Delivery Systems: Foods, Plant Matrices, Functional Foods, and Nutraceuticals4. Bioaccessibility, Bioavailability and Bioactivity: Clarification of the Concepts, Key Challenges, and Future DirectionsSection 2: Mechanisms of Absorption and Impact on Health5. Process of Absorption, Distribution, Metabolism, and Excretion (ADME) of Bioactive Compounds6. Impact of the Interaction of Bioactive Compounds within the Food Matrix on Their Bioaccessibility, Bioactivity, and Bioavailability7. Role of the Gut Microbiota in the Absorption Processes of Bioactive Compounds8. Human biochemistry of absorption and biotransformation of bioactive compounds: clinical trials and physiological applications9. Influence of bioaccessibility and bioavailability on human health: role in the prevention and management of chronic diseasesSection 3: Factors Affecting Bioaccessibility and Bioavailability10. Factors That Affect the Bioaccessibility and Bioavailability of Bioactive Compounds11. Methods for the Determination of Bioaccessibility and Bioavailability of Bioactive Compounds: Traditional Approaches, Microfluidic and New Techniques12. Strategies and Delivery Systems to Improve Bioaccessibility and Bioavailability of Bioactive Compounds: Limitations, Micro and NanoencapsulationSection 4: Innovative Approaches and Future Directions13. In Vivo, In Vitro, or In Silico Tools for Predicting Pharmacokinetics of Bioactive Compounds14. Can Informatics, Bioinformatics, and Artificial Intelligence Tools Help in the Study of Bioaccessibility and Bioavailability?15. Innovative Product Development for Enhancing Bioaccessibility and Bioavailability of Bioactive Compounds: Practical Examples and Applications