JOSEPH B. KADANE is Leonard J. Savage Professor of Statistics and Social Sciences at Carnegie Mellon University. He has published over one hundred papers on statistical theory and applications, edited the book Robustness of Bayesian Analysis, and coedited Statistics and the Law.

• Partial table of contents: MAJOR ISSUES. Ethically Optimizing Clinical Trials (K. Schaffner). Admissibility of Treatment (N. Sedransk). TEST CASE: VERAPAMIL/NITROPRUSSIDE. The Mechanics of Conducting a Clinical Trial (E. Heitmiller &T. Blanck). Issues of Statistical Design (N. Sedransk). Operational History and Procedural Feasibility (J. Kadane). Verapamil versus Nitroprusside: Results of the Clinical Trial I (J.Kadane & N. Sedransk). Verapamil versus Nitroprusside: Results of the Clinical Trial II(E. Heitmiller, et al.). OTHER ISSUES. Author's Response to Commentaries I and II (D. Kairys). EPILOGUE. Epilogue (J. Kadane). Indexes.

"...Every practitioner and associated statistician involved in a clinical trial should read this book..." (Statistical Methods in Medical Research, No.11, 2002)

JOSEPH B. KADANE is Leonard J. Savage Professor of Statistics and Social Sciences at Carnegie Mellon University. He has published over one hundred papers on statistical theory and applications, edited the book Robustness of Bayesian Analysis, and coedited Statistics and the Law.

• Partial table of contents: MAJOR ISSUES. Ethically Optimizing Clinical Trials (K. Schaffner). Admissibility of Treatment (N. Sedransk). TEST CASE: VERAPAMIL/NITROPRUSSIDE. The Mechanics of Conducting a Clinical Trial (E. Heitmiller &T. Blanck). Issues of Statistical Design (N. Sedransk). Operational History and Procedural Feasibility (J. Kadane). Verapamil versus Nitroprusside: Results of the Clinical Trial I (J.Kadane & N. Sedransk). Verapamil versus Nitroprusside: Results of the Clinical Trial II(E. Heitmiller, et al.). OTHER ISSUES. Author's Response to Commentaries I and II (D. Kairys). EPILOGUE. Epilogue (J. Kadane). Indexes.

"...Every practitioner and associated statistician involved in a clinical trial should read this book..." (Statistical Methods in Medical Research, No.11, 2002)

JOSEPH B. KADANE is Leonard J. Savage Professor of Statistics and Social Sciences at Carnegie Mellon University. He has published over one hundred papers on statistical theory and applications, edited the book Robustness of Bayesian Analysis, and coedited Statistics and the Law.

• Partial table of contents: MAJOR ISSUES. Ethically Optimizing Clinical Trials (K. Schaffner). Admissibility of Treatment (N. Sedransk). TEST CASE: VERAPAMIL/NITROPRUSSIDE. The Mechanics of Conducting a Clinical Trial (E. Heitmiller &T. Blanck). Issues of Statistical Design (N. Sedransk). Operational History and Procedural Feasibility (J. Kadane). Verapamil versus Nitroprusside: Results of the Clinical Trial I (J.Kadane & N. Sedransk). Verapamil versus Nitroprusside: Results of the Clinical Trial II(E. Heitmiller, et al.). OTHER ISSUES. Author's Response to Commentaries I and II (D. Kairys). EPILOGUE. Epilogue (J. Kadane). Indexes.

"...Every practitioner and associated statistician involved in a clinical trial should read this book..." (Statistical Methods in Medical Research, No.11, 2002)