Animal Models

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• Have animal models of disease helped or hindered the drug discovery process? / Ann Jacqueline Hunter Current models and strategies in the development of antiobesity drugs / James S. Kinsey-Jones and Kevin G. MurphyRelevance of angiotensin II-induced aortic pathologies in mice to human aortic aneurysms / Dennis Bruemmer [and others]Novel, nonreflex tests detect analgesic action in rodents at clinically relevant concentrations / Nick Andrews [and others]Animal welfare and the 3Rs in European biomedical research / Dominic J. WellsBest practices for the use of animals in toxicological research and testing / William S. StokesProgress toward generating informative porcine biomedical models using induced pluripotent stem cells / Franklin West and Steven SticeA knockout mouse resource for the biomedical research community / K.C. Kent LloydMinimizing strain influences in a genetically modified mouse phenotyping platform / Michael D. Hayward, Olesia Buiakova, and David S. GrassThe blessings and curses of C57BL/6 substrains in mouse genetic studies / Camron D. BryantModeling inflammation and microvascular dysfunction / Felicity N.E. GavinsTRPV1 and TRPA1 channels in inflammatory pain : elucidating mechanisms / Susan D. BrainImaging of endocrine gene expression in a humanized transgenic rat / Julian R.E. DavisSystems biology of the heart : hype or hope? / T. Alexander Quinn and Peter KohlIs it time for in silico simulation of drug cardiac side effects? / Gary R. Mirams and Denis NobleHuman stem cell-derived cardiomyocytes for pharmacological and toxicological modeling / Sian E. HardingHumanized mice as a preclinical tool for infectious disease and biomedical research / Leonard D. Shultz [and others]Humanized mice for the study of type 1 and type 2 diabetes / Dale L. Greiner [and others]Deconstructing hepatitis C virus infection in humanized mice / Marcus Dorner and Alexander PlossAnimal models got you puzzled? : think pig / Eric M. Walters [and others]