Age-Related Macular Degeneration

Jay S. Duker, MD is professor and chair of the Department of Ophthalmology at Tufts Medical Center and Tufts University School of Medicine and the Director of the New England Eye Center in Boston. Dr. Duker received his medical degree magna cum laude from Jefferson Medical College in Philadelphia. He completed an internal medicine internship at the Beth Israel Hospital in Boston. Dr. Duker then completed an ophthalmology residency, serving as chief resident, followed by a retina and vitreous surgery fellowship, at the Wills Eye Hospital in Philadelphia.Dr. Duker’s major research interests include imaging of the posterior segment, retinal vascular disease, and drug delivery to the posterior segment. He has pursued those interests as a coinvestigator or principal investigator of numerous studies funded by the National Institutes of Health/National Eye Institute, Massachusetts Institute of Technology, and industry, including studies of optical coherence tomography and several phase III trials. Specializing in medical and surgical diseases of the posterior segment, his surgical expertise includes macular diseases, retinal detachment, proliferative vitreoretinopathy, diabetic retinopathy, and intraocular tumors. He has published more than 180 journal articles, and he has been lead editor on 3 books and 13 book chapters. In addition, Dr. Duker lectures extensively both nationally and internationally. He is an associate editor of Ophthalmic Surgery and Laser Therapy and has served on the editorial boards of Review of Ophthalmology, Evidence-Based Eye Care, and Retina Today. He has been a reviewer for many journals, including Ophthalmology, American Journal of Ophthalmology, Archives of Ophthalmology, Ophthalmic Surgery and Lasers, Retina, and The New England Journal of Medicine, among others. Dr. Duker is the recipient of the Honor Award and Senior Honor Award from the American Academy of Ophthalmology.Andre J. Witkin, MD was born in Waterville, Maine. He attended Dartmouth College, earning his bachelor’s degree magna cum laude with high honors in biology. He earned his MD from Weill Cornell Medical College in New York City and did his ophthalmology residency at the New England Eye Center of Tufts Medical Center in Boston. Dr. Witkin then did a 2-year fellowship in retinal disease and vitreoretinal surgery at the Wills Eye Institute in Philadelphia. In 2012, he joined the ophthalmology faculty at the New England Eye Center of Tufts Medical Center as an assistant professor. Dr. Witkin has a special interest in clinical research, particularly in the field of retinal imaging. He has published more than 30 articles in peer-reviewed journals and several book chapters and has presented at more than a dozen national meetings in the field of ophthalmology. Dr. Witkin is currently the primary investigator for a number of clinical trials in macular degeneration and central serous chorioretinopathy at the New England Eye Center.

• Dedication About the Editors Contributing Authors Preface Chapter 1 Epidemiology, Genetics, and Modifiable Risk Factors Anita Agarwal, MD Chapter 2 Pathology of Age-Related Macular Degeneration Nora M.V. Laver, MD Chapter 3 Clinical Diagnosis, Classification, and Patient Counseling Sana Nadeem, MBBS and Nadia K. Waheed, MD, MPH Chapter 4 Ancillary Testing in Age-Related Macular Degeneration Section 1: Fundus Photography and Autofluorescence S.K. Steven Houston III, MD and Sunir J. Garg, MD, FACS Section 2: Optical Coherence Tomography Andre J. Witkin, MD Section 3: Fluorescein Angiography and Indocyanine Green Angiography Michael D. Tibbetts, MD and Elias Reichel, MD Chapter 5 Mimickers of Age-Related Macular Degeneration Kapil G. Kapoor, MD and Sophie J. Bakri, MD Chapter 6 Intravitreal Anti-Vascular Endothelial Growth Factor Therapy Mariana R. Thorell, MD and Philip J. Rosenfeld, MD, PhD Chapter 7 Thermal Laser and Photodynamic Therapy Llewelyn J. Rao, MD and Lawrence J. Singerman, MD, FACS Chapter 8 Treatment Failures: Nonresponders, Tolerance, and Tachyphylaxis Christopher J. Brady, MD and Chirag P. Shah, MD, MPH Chapter 9 Surgery for Age-Related Macular Degeneration Christopher J. Brady, MD and Carl D. Regillo, MD Chapter 10 Future Therapies Roger A. Goldberg, MD, MBA and Jeffrey S. Heier, MD Appendix Financial Disclosures Index

“This is an excellent, easily digestible book for eye care professionals at all levels. It effectively provides a thorough and comprehensive foundation for the understanding of age-related macular degeneration."- Hercules D. Logothetis, BS, MD, Northwestern University Feinberg School of Medicine, Doody’s Review Service