Advances in Nucleic Acid Therapeutics

• History and Development of Nucleotide Analogues in Nucleic Acids Drugs;Mechanisms of Antisense Oligonucleotides;The Medicinal Chemistry of RNase H-activating Antisense Oligonucleotides;Antisense Technology: Liver Targeting and Beyond for Drug Discovery;Oligonucleotide-based Toll-like Receptor Antagonists and Therapeutic Applications;Splicing Modulation for Therapeutics;Targeting Toxic Repeats;Research and Development of Oligonucleotides Targeting MicroRNAs (miRNAs);Oligonucleotide Targeting of Long Non-coding RNAs;Conjugate-mediated Delivery of RNAi-based Therapeutics: Enhancing Pharmacokinetics-Pharmacodynamics Relationships of Medicinal Oligonucleotides;Liver-targeted RNAi Therapeutics: Principles and Applications;Advances and Challenges of RNAi-Based Anti-HIV Therapeutics;Nucleic Acid Innate Immune Receptors;Synthetic Agonists of Toll-like Receptors and Therapeutic Applications;Prostate-specific Membrane Antigen (PSMA) Aptamers for Prostate Cancer Imaging and Therapy;Aptamers and Clinical Applications;CRISPR-based Technologies for Genome Engineering: Properties, Current Improvements and Applications in Medicine;Therapeutic Potential of Ribozymes;Large-scale Automated Synthesis of Therapeutic Oligonucleotides: A Status Update;Preclinical and Clinical Drug-metabolism, Pharmacokinetics and Safety of Therapeutic Oligonucleotides;Subject Index

This book is a go-to resource for those focusing on drug discovery and development. Each chapter in this volume contains contributions by experts in their respective fields. It has captured the many approaches currently being pursued in both academia and industry, providing an excellent account of research and methods of contemporary interest in nucleic acid therapeutics. I highly recommend this book to students and researchers interested in drug development, but especially to those searching for starting points for future research in DNA/RNA-based therapeutics.