Accurate Results in the Clinical Laboratory

Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.

• Chapter 1. Variation, Errors, and Quality in the Clinical LaboratoryChapter 2. Effect of Age, Gender, Diet, Exercise and Ethnicity on Laboratory Test ResultsChapter 3. Effect of patient preparation, specimen collection, anticoagulants and preservatives on laboratory testsChapter 4. Sample processing and specimen misidentification issuesChapter 5. Hemolysis, lipemia and high bilirubin: effect on laboratory testsChapter 6. Immunoassay design and mechanism of interferencesChapter 7. Effect of herbal remedies on clinical laboratory testsChapter 8. Challenges in routine clinical chemistry: analysis of small moleculesChapter 9. Challenges in routine clinical chemistry: proteins and enzymesChapter 10. Sources of inaccuracy in biochemical genetics analysisChapter 11. Challenges in endocrinology testingChapter 12. Pitfalls in tumor marker testingChapter 13. Issues of interferences in therapeutic drug monitoringChapter 14. Limitations of drugs of abuse testingChapter 15. Challenges in confirmation testing for drugs of abuseChapter 16. Alcohol determination using automated analyzers: limitations and pitfallsChapter 17. Pre-analytical issues and interferences in transfusion medicine testsChapter 18. Critical issues in immunology and serology testingChapter 19. Sources of errors in hematology and coagulation testingChapter 20. Challenges in Clinical Microbiology TestingChapter 21. Sources of errors in molecular testingChapter 22. Problems in Pharmacogenomics Testing

"Dasgupta and Sepulveda offer clinicians and laboratory scientists a guide to error detection and correction in the clinical laboratory that addresses sources of errors in analytical methods and sources of pre-analytical variation." --Reference and Research Book News, August 2013"This is a very helpful book correlating nonanalytical measurement errors or disease states with anticipated effects on laboratory test results. This would be a must for the laboratory medicine resident who has to explain why results don't correlate with clinical disease." --Doody.com, August 9, 2013