5-HT2C Receptors in the Pathophysiology of CNS Disease

Häftad, Engelska, 2013

Av Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo

3 759 kr

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Part of Springer’s “The Receptors,” series, this text is the first ever overview on the research of 5-HT2c receptors. 5-HT2c receptor research has been productive for twenty-five years, but recent years have seen an extraordinary increase in both amount produced and insight gained. 5-HT2c is a prominent central serotonin receptor subtype widely expressed within the central and the peripheral nervous system and is thought to play a key role in the regulation of numerous behaviors. This text covers the molecular, cellular, anatomical, biochemical and behavioral aspects of this receptor, highlighting its distinctive regulatory properties and the emerging functional significance of constitutive activity and RNA-editing in vivo. It also investigates the receptors’ therapeutic potential in many diseases, treated individually in separate chapters, including depression, drug abuse, schizophrenia, eating disorders, Parkinson’s disease, Prader-Willi Syndrome, Alzheimer’s disease and epilepsy.

Produktinformation

Utgivningsdatum2013-01-28
Mått155 x 235 x 31 mm
Vikt855 g
SpråkEngelska
SerieReceptors
Antal sidor560
Upplaga2011
FörlagHumana Press Inc.
EAN9781617797200

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The making of the 5-HT2C receptor.- Serotonin 5-HT2C receptors: chemical neuronatomy in the mammalian brain.- The medicinal chemistry of 5-HT2C receptor ligands.- Insights into 5-HT2C receptor function gained from transgenic mouse models.- Serotonin 5-HT2C receptor signal transduction.- Homology modeling of 5-HT2C receptors.- 5-HT2C receptor dimerization.- RNA editing of 5-HT2C receptor and neuropsychiatric diseases.- Serotonergic control of adult neurogenesis: focus on 5-HT2C receptors.- The constitutive activity of 5-HT2C receptors as an additional modality of interaction of the serotonergic system.- The 5-HT2C receptor subtype controls central dopaminergic systems: evidence from electrophysiological and neurochemical studies.- The role of serotonin-2C receptors in the pathophysiology of depression.- 5-HT2C receptors and suicidal behaviour.- The 5-HT2C receptor as a target for schizophrenia.- Serotonin and reward-related behaviour: focus on 5-HT2C receptors.- Tat-3L4F: a novel peptide for treating drug addiction by disrupting interaction between PTEN and 5-HT2C receptor.- The role of serotonin in eating behaviour: focus on 5-HT2C receptors.- Physiological and pathophysiological aspects of 5-HT2C receptors in basal ganglia.- Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment.- The role of 5-HT2A/2C receptors in sleep and waking.- Role of alternative splicing of the 5-HT2C in the Prader-Willi syndrome.- The role of 5-HT2C receptor in epilepsy.- The role of serotonin on attentional processes and executive functioning: focus on 5-HT2C receptors.- 5-HT2C receptors in learning.- The role of 5-HT2C polymorphisms in behavioural and psychological symptoms of alzheimer's disease.- Ocular hypotension: involvement of serotonergic 5-HT2C receptors.

From the reviews: "The book is well presented with good use of diagrams ... . There is a good mix of international authors with acknowledged leaders in the field being responsible for some key chapters. ... In summary this is a useful book describing the properties of a receptor that may well turn out to be a therapeutically important drug target with selective ligands already being evaluated in phase II trials for control of appetite." (R. G. Hill, British Journal of Clinical Pharmacology, May, 2011)