5-HT2C Receptors in the Pathophysiology of CNS Disease

• The making of the 5-HT2C receptor.- Serotonin 5-HT2C receptors: chemical neuronatomy in the mammalian brain.- The medicinal chemistry of 5-HT2C receptor ligands.- Insights into 5-HT2C receptor function gained from transgenic mouse models.- Serotonin 5-HT2C receptor signal transduction.- Homology modeling of 5-HT2C receptors.- 5-HT2C receptor dimerization.- RNA editing of 5-HT2C receptor and neuropsychiatric diseases.- Serotonergic control of adult neurogenesis: focus on 5-HT2C receptors.- The constitutive activity of 5-HT2C receptors as an additional modality of interaction of the serotonergic system.- The 5-HT2C receptor subtype controls central dopaminergic systems: evidence from electrophysiological and neurochemical studies.- The role of serotonin-2C receptors in the pathophysiology of depression.- 5-HT2C receptors and suicidal behaviour.- The 5-HT2C receptor as a target for schizophrenia.- Serotonin and reward-related behaviour: focus on 5-HT2C receptors.- Tat-3L4F: a novel peptide for treating drug addiction by disrupting interaction between PTEN and 5-HT2C receptor.- The role of serotonin in eating behaviour: focus on 5-HT2C receptors.- Physiological and pathophysiological aspects of 5-HT2C receptors in basal ganglia.- Modeling tardive dyskinesia: predictive 5-HT2C receptor antagonist treatment.- The role of 5-HT2A/2C receptors in sleep and waking.- Role of alternative splicing of the 5-HT2C in the Prader-Willi syndrome.- The role of 5-HT2C receptor in epilepsy.- The role of serotonin on attentional processes and executive functioning: focus on 5-HT2C receptors.- 5-HT2C receptors in learning.- The role of 5-HT2C polymorphisms in behavioural and psychological symptoms of alzheimer's disease.- Ocular hypotension: involvement of serotonergic 5-HT2C receptors.

From the reviews: "The book is well presented with good use of diagrams ... . There is a good mix of international authors with acknowledged leaders in the field being responsible for some key chapters. ... In summary this is a useful book describing the properties of a receptor that may well turn out to be a therapeutically important drug target with selective ligands already being evaluated in phase II trials for control of appetite." (R. G. Hill, British Journal of Clinical Pharmacology, May, 2011)