Wound Closure Biomaterials and Devices

Chin-Chang Chu, J. Anthony von Fraunhofer, Howard P. Greisler

• Introduction, C.C. Chu Wound Healing and Inflammatory Response to Biomaterials, P.H. Lin, M.K. Hirko, J.A. von Fraunhofer, and H.P. Greisler Introduction Biological Tissues Inflammation and Wound Healing Foreign-Body Reactions Fibrosis and Fibrous Encapsulation Growth Factors Affecting Wound Healing Summary Surgical Needles, J.A. von Fraunhofer and C.C. Chu Introduction Needle Dimensions Needle-Suture Attachment The Needle Body Needle Points Needle Acuity Needle Biomechanics Needle Holders Summary Classification and General Characteristics of Suture Materials, C.C. Chu Absorbable vs. Nonabsorbable Suture Size Multifilament vs. Monofilament Coating Materials Four General Characteristics Summary Chemical Structure and Manufacturing Processes, C.C. Chu Absorbable Sutures Non-Absorbable Sutures Mechanical Properties, J.A. von Fraunhofer and C.C. Chu Tensile Properties Stiffness and Flexibility Viscoelastic Properties Knot Strength and Security Summary Biodegradation Properties, C.C. Chu General Biodegradation Phenomena Natural Absorbable Sutures Synthetic Absorbable Sutures Nonabsorbable Suture Materials Biological Properties of Suture Materials, M.K. Hirko, P.H. Lin, H.P. Greisler, and C.C. Chu General Tissue Reactions and Cellular Response Granuloma Formation Wound Infection Thrombogenicity Formation of Urinary Calculi Carcinogenicity Summary Suture Techniques and Selection, H.P. Greisler Surgical Principles (W. Irvin) Cardiovascular System (S.S. Kang and H.P. Greisler) Abdominal System (S.S. Kang and H.P. Greisler) Bronchial, Tracheal, and Chest System (S.S. Kang and H.P. Greisler) Obstetrics and Gynecologic System (W. Irvin) Orthopaedic System (J.R. Perez-Sanz) Ligating Clips and Staplers, J.A. von Fraunhofer Introduction Metallic Ligating Clips Polymeric Ligating Clips Other Ligating Clips Surgical Staples Staples and Clips vs. Sutures? Summary Tissue Adhesives, Y. Ikada Design Principles of Tissue Adhesives Natural Tissue Adhesion SystemoFibrin Glue Synthetic T