Workbook for Organic Synthesis

Strategy and Control

Inbunden, Engelska, 2008

AvPaul Wyatt,Stuart Warren

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Workbook for Organic Synthesis: Strategy and Control Paul Wyatt Senior Lecturer and Director of Undergraduate Studies, School of Chemistry, University of Bristol, UK Stuart Warren Reader in Organic Chemistry, Department of Chemistry, University of Cambridge, UK. Workbook for Organic Synthesis: Strategy and ControlThis workbook provides a comprehensive graded set of problems to illustrate and develop the themes of each of the chapters in the textbook Organic Synthesis: Strategy and Control. Each problem is followed by a fully explained solution and discussion. The examples extend the student's experience of the types of molecules being synthesised by organic chemists, and the strategies they employ to control their syntheses. By working through these examples students will develop their skills in analysing synthetic challenges, and build a toolkit of strategies for planning new syntheses. Together the workbook and textbook provide a complete course in advanced organic synthesis. Organic Synthesis: Strategy and ControlOrganic Synthesis: Strategy and Control is a sequel to Stuart Warren's bestseller Organic Synthesis: The Disconnection Approach. The 'Disconnection' book concentrated on the planning behind the synthesis of compounds. This book focuses on putting the planning into practice. The two themes of the book are strategy and control: solving problems either by finding an alternative strategy or by controlling any established strategy to make it work. The book is divided into five sections that deal with selectivity, carbon-carbon single bonds, carbon-carbon double bonds, stereochemistry and functional group strategy. Interpenetrating this structure, the 36 chapters start with classic methods and progress to modern methods and modern strategic considerations. Heterocyclic chemistry is treated throughout the book with full mechanistic explanations as part of organic chemistry rather than a separate entity. Students and professional chemists familiar with Organic Synthesis: The Disconnection Approach will enjoy the leap into a book designed for chemists at the coalface of organic synthesis.

Produktinformation

Utgivningsdatum2008-04-21
Mått194 x 254 x 34 mm
Vikt1 134 g
FormatInbunden
SpråkEngelska
Antal sidor500
FörlagJohn Wiley & Sons Inc
ISBN9780470758830

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Organisk kemi inom Naturvetenskap och teknik

Dr Paul Wyatt, School of Chemistry, University of Bristol, BristolDr Wyatt is Director of Undergraduate Studies for the School of Chemistry at Bristol University and also Director of BRISTOL ChemLabS - a HEFCE Centre for Excellence in Teaching & Learning.Dr Stuart Warren, Department of Chemistry, University of Cambridge, Lensfield Road, CambridgeDr Warren is the author of the bestselling textbooks Organic Synthesis: The Disconnection Approach (Wiley) and Organic Synthesis (OUP)

Preface viiA: Introduction: Selectivity 11. Planning Organic Syntheses: Tactics, Strategy and Control 32. Chemoselectivity 73. Regioselectivity: Controlled Aldol Reactions 194. Stereoselectivity: Stereoselective Aldol Reactions 355. Alternative Strategies for Enone Synthesis 476. Choosing a Strategy: The Synthesis of Cyclopentenones 57B: Making Carbon–Carbon Bonds 697. The Ortho Strategy for Aromatic Compounds 718. σ-Complexes of Metals 919. Controlling the Michael Reaction 10310. Specific Enol Equivalents 11511. Extended Enolates 12312. Allyl Anions 13513. Homoenolates 14714. Acyl Anion Equivalents 155C: Carbon–Carbon Double Bonds 16915. Synthesis of Double Bonds of Defined Stereochemistry 17116. Vinyl Anions 19117. Electrophilic Attack on Alkenes 20318. Vinyl Cations 22119. Allyl Alcohols: Allyl Cation Equivalents (and More) 241D: Stereochemistry 25720. Control of Stereochemistry–Introduction 25921. Diastereoselectivity 26922. Resolution 28323. The Chiral Pool: Asymmetric Synthesis with Natural Products as Starting Materials 29524. Asymmetric Induction I: Reagent-Based Strategy 30925. Asymmetric Induction II: Asymmetric Catalysis: Formation of C–O and C–N Bonds 32126. Asymmetric Induction III: Asymmetric Catalysis: Formation of C–H and C–C Bonds 33527. Asymmetric Induction IV: Substrate-Based Strategy 35128. Kinetic Resolution 36529. Enzymes: Biological Methods in Asymmetric Synthesis 37730. New Chiral Centres from Old: Enantiomerically Pure Compounds and Sophisticated Syntheses 39131. Strategy of Asymmetric Synthesis 405E: Functional Group Strategy 41732. Functionalisation of Pyridine 41933. Oxidation of Aromatic Rings and of Enol(ate)s 43334. Functionality and Pericyclic Reactions: Nitrogen Heterocycles by Cycloadditions and Sigmatropic Rearrangements 44735. Synthesis and Chemistry of Azoles and other Heterocycles with Two or more Heteroatoms 45936. Tandem Organic Reactions 473Index 483