Derek G. Waller, BSc, DM, MBBS, FRCP, Consultant Cardiovascular Physician, Southampton General Hospital; Senior Lecturer in Medicine and Clinical Pharmacology, University of Southampton, Southampton, UK Dagan Lonsdale, BSc(Hons) MBBS MRCP FHEA, Honorary Senior Lecturer, St George's, University of London; Specialty Registrar in Clinical Pharmacology, General Medicine and Intensive Care Medicine, St George's University Hospitals NHS Foundation Trust, London, UK

• SECTION 1 GENERAL PRINCIPLES1. Principles of Pharmacology and Mechanisms of Drug Action2. Pharmacokinetics3. Drug Discovery, Safety and Efficacy4. Neurotransmission and the Peripheral Autonomic Nervous SystemSECTION 2 THE CARDIOVASCULAR SYSTEM5. Ischaemic Heart Disease6. Systemic and Pulmonary Hypertension7. Heart Failure and Shock8. Cardiac Arrhythmias9. Cerebrovascular Disease and Dementia10. Peripheral Artery Disease11. HaemostasisSECTION 3 THE RESPIRATORY SYSTEM12. Asthma and Chronic Obstructive Pulmonary Disease13. Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress SyndromeSECTION 4 THE RENAL SYSTEM14. Diuretics15. Disorders of Micturition16. Erectile DysfunctionSECTION 5 THE NERVOUS SYSTEM17. General Anaesthetics18. Local Anaesthetics19. Opioid Analgesics and the Management of Pain20. Anxiety, Obsessive-Compulsive Disorder and Insomnia21. Schizophrenia and Bipolar Disorder22. Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy23. Seizures and Epilepsy24. Extrapyramidal Movement Disorders and Spasticity25. Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain-Barré Syndrome26. Migraine and Other HeadachesSECTION 6 THE MUSCULOSKELETAL SYSTEM27. The Neuromuscular Junction and Neuromuscular Blockade28. Myasthenia Gravis29. Nonsteroidal Anti-inflammatory Drugs30. Rheumatoid Arthritis, Other Inflammatory Arthritides and Osteoarthritis31. Hyperuricaemia, Gout and PseudogoutSECTION 7 THE GASTROINTESTINAL SYSTEM32. Nausea and Vomiting33. Dyspepsia, Peptic Ulcer Disease and Gastrooesophageal Reflux Disease34. Inflammatory Bowel Disease35. Constipation, Diarrhoea and Irritable Bowel Syndrome36. Liver Disease37. ObesitySECTION 8 THE IMMUNE SYSTEM38. The Immune Response and Immunosuppressant Drugs39. Antihistamines and Allergic DiseaseSECTION 9 THE ENDOCRINE SYSTEM AND METABOLISM40. Diabetes Mellitus41. The Thyroid and Control of Metabolic Rate42. Calcium Metabolism and Metabolic Bone Disease43. Pituitary and Hypothalamic Hormones44. Corticosteroids (Glucocorticoids and Mineralocorticoids)45. Female Reproduction46. Androgens, Antiandrogens and Anabolic Steroids47. Anaemia and Haematopoietic Colony-Stimulating Factors48. Lipid DisordersSECTION 10 THE SKIN AND EYES49. Skin Disorders 50. The EyeSECTION 11 CHEMOTHERAPY51. Drugs for Infections52. Drugs for CancerSECTION 12 GENERAL FEATURES, TOXICITY AND PRESCRIBING53. Drug Toxicity and Overdose54. Substance Abuse and Dependence55. Prescribing, Adherence and Information About Medicines56. Drug Therapy in Special Situations Index

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