Voltage-Gated Calcium Channels

Häftad, Engelska, 2023

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This book includes unparalleled insights into structural features of calcium channels due to X-ray crystallography and cryo-EM, which in turn yielded critical information into how these channels function under normal and pathophysiological conditions, and how they interact with calcium channel therapeutics.

Produktinformation

Utgivningsdatum2023-11-10
Mått178 x 254 x 39 mm
Vikt1 330 g
FormatHäftad
SpråkEngelska
Antal sidor710
FörlagSpringer International Publishing AG
ISBN9783031088834

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Tillämpad fysik inom Naturvetenskap och teknik
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Fysiologi inom Medicin

1. Measuring and manipulating calcium.- 2. Structure, function and subunit assembly of VGCC.- 3. Splice variation and RNA editing of VGCCs.- 4. Mechanisms of calcium channel permeation.- 5. Regulation by beta subunits .- 6. Regulation by alpha2 delta subunits.- 7. VGCCs in invertebrates.- 8. Modulation by GPCRs and second messengers.- 9. Trafficking of VGCCs.- 10. Calcium regulation.- 11. Calcium channel complexes with other channels.- 12. Regulation of gene transcription by VGCCs.- 13. Lessons from knock-out and knock-in mice.- 14. VGCCs and synaptic transmission.- 15. Cardiovascular syste.- 16. Calcium channels and exocytosis in chromaffin cells.- 17. Calcium channels in the pancreas in health and disease.- 18. Skeletal muscle system.- 19. Auditory and visual systems.- 20. Calcium channels and pain transmission.- 21. Migraine.- 22. Epilepsy.- 23. Psychiatric disorders.- 24. Parkinson’s disease.-25. Reproductive system.- 26. Cancer.- 27. Molecular determinants of VGCC pharmacology.- 28. Interactions with peptide toxins.- 29. Clinical pharmacology and drug discovery.