Vitamin D

A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994

Inbunden, Engelska, 1994

Av Anthony W. Norman, Roger Bouillon, Monique Thomasset

5 819 kr

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Produktinformation

Utgivningsdatum1994-11-01
Mått170 x 240 x undefined mm
Vikt1 960 g
FormatInbunden
SpråkEngelska
Antal sidor1 002
FörlagDe Gruyter
ISBN9783110141573

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Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1?-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1?,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2?-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of