Vitamin D. Basic Research and its Clinical Application

Proceedings of the Fourth Workshop on Vitamin D, Berlin, West Germany, February 1979

Inbunden, Engelska, 1979

Av A. W. Norman, K. Schaefer, D. v. Herrath, H.-G. Grigoleit, J. W. Coburn, H. F. De Luca, E. B. Mawer, T. Suda, D. V. Herrath, H. F. de Luca, H. -G. Grigoleit

7 499 kr

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Produktinformation

Utgivningsdatum1979-12-31
Mått175 x 246 x 83 mm
Vikt2 402 g
FormatInbunden
SpråkEngelska
Antal sidor1 344
Upplaga79001
FörlagDe Gruyter
ISBN9783112330012

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Klinisk medicin och internmedicin inom Medicin

Frontmatter -- Foreword -- Contents -- Chemistry, Structure, Function and Biological Assay -- Introduction -- Synthesis of Some Side Chain Analogues of Vitamin D3 Metabolites -- Structural Transformations on Vitamin D -- Distribution and Activity of a Vitamin D3 Compound in Trisetum Flavescens -- Synthesis and Biological Activity of 24R-Hydroxy-25-fluorocholecalciferol and 1a, 24R-Dihydroxy-25-fluorocholecalciferol -- The Synthesis and Biological Evaluation of Fluorinated Analoges as Probes of Vitamin Da Metabolism -- 19-Substituted-10,19-Dihydrovitamins via Hydrozirconation of Vitamin D3 -- The Synthesis of 1a, 3a-Dihydroxy-25Methylcholesta-5,7-Diene-24-OIC Acid, and of la, 3a-Dihydroxy-25 Methylcholesta-5,7-Diene -- Interconversion of Vitamin D and Trans-Vitamin D by Triplet-Sensitized Isomerization -- The Use of UV, CD, 2H-NMR Spectroscopy and Mass Spectrometry for the Investigation of Conformational Mobility of Vitamin D and Previtamin D and their Interconversion -- 25 (R), 26 and 25 (S), 26-(OH)2D3: Biological Activity in Intact and Nephrectomized Rats. Comparative Effects of 1, 25, 24 (R), 25-(OH)2D3 and I, 24 (R), 25-(OH)3D3 -- Inhibitors of Vitamin D Metabolism and Action -- C(1)-Hydroxylation of Vitamin D3 and Related Compounds -- Vitamin D3 Sulfate in Lactating normally fed Rats and Suckling Pups After Maternal Administration of 3H Vitamin D3 or 35S Vitamin D3 Sulfate -- Synthesis of Vitamin D Analogues and their Covalent Binding to Affinity Chromatographic Media -- Osteoporosis -- Calcium Absorption and Plasma 1,25 (OH)2D Levels in Post-Menopausal Osteoporosis -- Osteoporosis and Age-Related Osteopenia: Evaluation of Possible Role of Vitamin D Endocrine System in Pathogenesis of Intestinal Calcium Absorption -- Two Years Experience of Oral Treatment with 1a-Hydroxyvitamin D and Calcium in Patients with Senile or Postmenopausal Osteoporosis -- The Treatment of Osteoporosis with 24,25 Dihydroxycholecalciferol A Pilot Study -- Osteomalacic Factors in the Osteoporosis and the Treatment of Osteoporotic Patients with Vitamin D2 and 1aOHD3 -- Transcalciferan/D-Binding Protein(s) -- Biologic Significance of Genetic Variation in Human Gc (Vitamin D-Binding Protein) -- The Transport of Vitamin D -- Structure and Properties of Human Plasma Vitamin D Transport Protein (Group-Specific Component) -- Serum Vitamin D Binding and Gc Polymorphism -- Sunlight, Skin and Seasonal Effects -- Identification of in Vivo Generated Previtamin D3, Vitamin D3 and 25-Hydroxyvitamin D3 in the Vitamin D-Deficient Rats Irradiated by Ultraviolet Light -- Response of Plasma 250HD to Standardized Ultra Violet Radiation -- Effects of Sunlight Exposure on Blood Concentration of Vitamin D Derivatives in Healthy Japanese Adults -- Contribution of Skin Vitamin D3 Synthesis in Patients Receiving Total Parenteral Nutrition -- The Photo-Biochemistry of Vitamin D3 in Vivo in the Skin -- Assays for Vitamin D Metabolites -- Measurement of Plasma 1,25 (OH)2 Vitamin D by Protein Binding Assay and Radioimmunoassay -- Use of Isotope Dilution Mass Fragmentography in Vitamin D Research -- Assay of 1,25-Dihydroxyvitamin D and Other Active Vitamin D Metabolites in Serum: Application to Animals and Humans -- 24,25-Dihydoxyvitamin D in Human Serum -- Radioimmunoassay of Vitamin D Metabolites -- Assays for Vitamin D and its Metabolites -- Radioimmunoassay for Circulating 1,25- and 25,26-Dihydroxycholecaliferols in Man -- Hemisuccinates of Vitamin D3 and of its Metabolites -- Studies on Antisera against Vitamin D Metabolites -- The Measurement of Various Vitamin D Derivatives in Plasma Using High-Pressure Liquid Chromatography -- Assay of 1,25- and 24,25 Dihydoxycholecalciferol in Human Serum - some Technical Considerations -- Radiocompetitive Protein Binding Assays for 25-Hydroxy Vitamin D, 24,25-Dihydroxyvitamin D and 1,25-Dihydroxy-vitamin D in Human Serum -- Steroid Receptors: What do We not Know? -- Vitamin D - Parathyroid Hormone -- Cholecalcifediol suppression of PTH

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