Dmitrij Frishman is Professor for Bioinformatics at Munich Technical University (TUM)Manja Marz is Professor for High-Throughput Sequencing Analysis at Friedrich Schiller University Jena

• Chapter 1 ◾ Comparative Genomics of VirusesThomas RatteiChapter 2 ◾ Current Techniques and Approaches for Metagenomic Exploration of Phage DiversitySimon Roux and Mark BorodovskyChapter 3 ◾ Direct RNA Sequencing for Complete Viral GenomesSebastian Krautwurst, Ronald Dijkman, Volker Thiel,Andi Krumbholz, and Manja MarzChapter 4 ◾ Computational Methods for Viral Quasispecies AssemblyKim Philipp Jablonski and Niko BeerenwinkelChapter 5 ◾ Functional RNA Structures in the 3′ UTR of Mosquito-Borne FlavivirusesMichael T. Wolfinger, Roman Ochsenreiter, andIvo L. Hofackervi ◾ ContentsChapter 6 ◾ Structural Bioinformatics of Influenza Virus RNA GenomesAlexander P. Gultyaev, René C.L. Olsthoorn,Monique I. Spronken, and Mathilde RichardChapter 7◾ Structural Genomics and Interactomics of SARS-COV2: Decoding Basic Building Blocks of the Coronavirus Ziyang Gao, Senbao Lu, Oleksandr Narykov, SuhasSrinivasan, and Dmitry KorkinChapter 8 ◾ Computational Tools for Discovery of CD8 T cell Epitopes and CTL Immune Escape in Viruses Causing Persistent InfectionsHadi Karimzadeh, Daniel Habermann, Daniel Hoffmann,and Michael RoggendorfChapter 9 ◾ Virus-Host TranscriptomicsCaroline C. FriedelChapter 10 ◾ Sequence Classification with Machine Learning at the Example of Viral Host PredictionFlorian Mock and Manja MarzChapter 11 ◾ Master Regulators of Host Response to SARS-CoV-2 as Promising Targets for Drug RepurposingManasa KP , Kamilya Altynbekova, and Alexander KelChapter 12 ◾ The Potential of Computational Genomics in the Design of Oncolytic VirusesHenni Zommer and Tamir TullerChapter 13 ◾ Sharing Knowledge in VirologyEdouard De Castro, Chantal Hulo, Patrick Masson, andPhilippe Le Mercier

“Virology is progressing under the comfortable simplifications or reductionism and the disturbing recognition of complexity. Viruses are ubiquitous and diverse, and individual viral populations are exceedingly complex and dynamic, both genetically and phenotypically. As intracellular infection events are scrutinized at the single cell level of analysis, we are learning that virus-cell-organism interactions are multifaceted and intricate. Bioinformatics emerges to rescue virology amid a turmoil of new information in need of order. This book, edited by Manja Marz and Dimitrij Frishman, with outstanding contributing authors, will play the role of a lighthouse in a stormy ocean, to guide virologists on possible paths to follow.”-- Esteban Domingo, Professor of Research at the Spanish National Research Council (CSIC), Madrid, Winter 2021