This book constitutes the refereed proceeding of the 15th International Conference on Videogame Sciences and Arts, VJ 2025, held in Porto, Portugal, during December 4–5, 2025.The 18 full papers and 2 short papers presented in this volume were carefully reviewed and selected from 26 submissions. They are organized into the following topics: Serious Games, Gamification, and Applied Play; Accessibility, Inclusion, and Human-Centered Design; Artificial Intelligence, Procedural Generation, and Computational Approaches to Play; and Game Studies, Cultural Memory, and Critical Perspectives.