Veterinary Microbiology and Microbial Disease

Patrick Joseph Quinn MVB, PhD, MRCVS (deceased 2025) was Professor Emeritus of Veterinary Microbiology and Parasitology at the School of Veterinary Medicine, University College Dublin, IrelandBryan K. Markey MVB, PhD, DipStat, Dipl.ECVM, MRCVS is former Professor of Veterinary Microbiology and EBVS® European Specialist in Veterinary Microbiology at the School of Veterinary Medicine, University College Dublin, IrelandFinola C. Leonard MVB, PhD, Dipl.ECVM, MRCVS is Professor of Veterinary Microbiology and EBVS® European Specialist in Veterinary Microbiology at the School of Veterinary Medicine, University College Dublin, IrelandJoseph P. Cassidy MVB, PhD, FRCPath, MRCVS is Associate Professor of Veterinary Pathology at the School of Veterinary Medicine, University College Dublin, IrelandStephen V. Gordon BSc, PhD is Professor of Infection Biology at the Schools of Veterinary Medicine; Biomolecular and Biomedical Science; and Medicine, University College Dublin, IrelandSéamus Fanning BSc, PhD, FAAM, DSc is Professor of Food Safety and Zoonoses at the School of Public Health, Physiotherapy and Sports Science, University College Dublin, IrelandGerald Barry MSc, PhD is Assistant Professor of Virology at the School of Veterinary Medicine, University College Dublin, IrelandEamonn S. FitzPatrick FIBMS, FRMS is former Chief Technical Officer at the School of Veterinary Medicine, University College Dublin, IrelandAidan P. Kelly is former Chief Technical Officer at the School of Veterinary Medicine, University College Dublin, IrelandKieran G. Meade BAgrSc, PhD, Dipl. T&L is Professor of Immunobiology at the School of Agriculture and Food Science, University College Dublin, Ireland

• Preface ixAcknowledgements xAuthor biographies xiAbout the Companion Website xivSection I Introduction to Microbiology, Infection, Immunity and Molecular Diagnostic Methods1 Microbiology, microbial pathogens and infectious disease 32 Subdivisions, classification and morphological characterization of infectious agents 83 Immunity and infection 144 Immune system disorders 785 Vaccines and vaccination 966 Molecular diagnostic methods 114Section II Introductory Bacteriology7 The structure of bacterial cells and bacterial taxonomy 1438 Cultivation, preservation and inactivation of bacteria 1519 Bacterial genetics, mechanisms of genetic variation and gene databases 15810 Laboratory diagnosis of bacterial disease 17711 Antibacterial agents 18312 Antibacterial resistance 19213 Bacterial colonization, tissue invasion and clinical disease 202Section III Pathogenic Bacteria14 Overview of bacteria of veterinary importance 21715 Staphylococcus species 22516 Streptococcus species and Enterococcus species 23317 Actinomycetes 24218 Corynebacterium species 25319 Rhodococcus equi 26020 Listeria species 26421 Erysipelothrix rhusiopathiae 26922 Bacillus species 27323 Clostridium and Clostridioides species 28024 Mycobacterium species 29625 Enterobacterales 30926 Pseudomonas aeruginosa and Burkholderia species 33527 Actinobacillus species 34228 Pasteurella species, Mannheimia haemolytica and Bibersteinia trehalosi 34929 Francisella tularensis 35830 Histophilus somni, Glaesserella parasuis, Avibacterium paragallinarum and Gallibacterium anatis 36231 Taylorella species 36932 Bordetella species 37233 Moraxella species 37834 Brucella species 38235 Campylobacter and Helicobacter species 39036 Lawsonia intracellularis 39737 Spirochaetes 40038 Pathogenic anaerobic non-spore-forming Gram-negative bacteria 41539 Mycoplasmas 42140 Chlamydia species 43241 Rickettsiales and Coxiella burnetii 44242 Bacterial species of limited pathogenic significance in animals 453Section IV Mycology43 General features of fungi and an overview of their veterinary importance 46144 Dermatophytes 47145 Aspergillus species 47846 Yeasts and disease production 48447 Dimorphic fungi 49448 Zygomycetes of veterinary importance 50249 Fungus-like organisms of veterinary importance 50850 Pneumocystis species 51351 Opportunistic infections caused predominantly by phaeoid fungi 51652 Mycotoxins and mycotoxicoses 52053 Pathogenic algae and cyanobacteria 53554 Antifungal chemotherapy 541Section V Introductory Virology55 Nature, structure and taxonomy of viruses 56156 Replication of viruses 57257 Virus evolution 58058 Propagation of viruses and virus–cell interactions 58559 Pathogenesis of viral diseases 59060 Laboratory diagnosis of viral infections 59761 Antiviral chemotherapy 603Section VI Viruses and Prions62 Overview of viruses of veterinary importance 62363 Orthoherpesviridae 62864 Papillomaviridae 64565 Adenoviridae 65166 Poxviridae 65767 Asfarviridae 66868 Parvoviridae 67269 Circoviridae and Anelloviridae 68170 Retroviridae 68571 Sedoreoviridae and Spinareoviridae 70172 Birnaviridae 71073 Orthomyxoviridae 71474 Paramyxoviridae and Pneumoviridae 72375 Rhabdoviridae 73676 Bornaviridae 74377 Peribunyaviridae, Nairoviridae, Phenuiviridae and Hantaviridae 74678 Picornaviridae 75279 Caliciviridae 76280 Astroviridae 76881 Coronaviridae 77182 Arteriviridae 78483 Flaviviridae 79084 Togaviridae 80185 Prions: unconventional infectious agents 806Section VII Microbial Agents and Disease86 Lesions resulting from interaction of bacterial, fungal and viral pathogens with host organ systems 81787 Interactions of microbial pathogens with the nervous system 81988 Interactions of microbial pathogens with the male and female reproductive systems 82889 The role of microbial pathogens in intestinal and liver disease 83790 The role of microbial pathogens in respiratory disease 84991 Interactions of microbial pathogens with the urinary system 85992 Microbial diseases of the cardiovascular system 87093 Interactions of microbial pathogens with the musculoskeletal system 88094 The role of microbial pathogens in diseases of the integumentary system 89595 Bacterial causes of bovine mastitis 90896 Disinfection, biosecurity and other aspects of disease control 922Appendix: Relevant websites 966Index 969