This book constitutes the refereed proceedings of the 19th International Conference on Verification, Model Checking, and Abstract Interpretation, VMCAI 2018, held in Los Angeles, CA, USA, in January 2018.The 24 full papers presented together with the abstracts of 3 invited keynotes and 1 invited tutorial  were carefully reviewed and selected from 43 submissions. VMCAI provides topics including: program verification, model checking, abstract interpretation, program synthesis, static analysis, type systems, deductive methods, program certification, decision procedures, theorem proving, program certification, debugging techniques, program transformation, optimization, and hybrid and cyber-physical systems.