Vascular Responses to Pathogens

Inbunden, Engelska, 2015

AvFelicity N.E. Gavins,Karen Y. Stokes,USA) Gavins, Felicity N.E. (Associate Professor and Director of Small Animal Imaging Facility at LSU Health Sciences Center, Shreveport, LA,USA) Stokes, Karen Y. (Associate Professor, Department of Molecular and Cellular Physiology, Department of Microbiology & Immunology, Louisiana State University, Shreveport, LA,Felicity N. E. Gavins

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Vascular Responses to Pathogens focuses on the growing research from leaders in the field for both the short and long-term impact of pathogens on the vasculature. It discusses various organisms, including bacteria, parasites, and viruses, and their role in key events leading to vascular disease.

Formatted to discuss the topic of the interaction of pathogens with the vascular rather than individual diseases described separately, this reference demonstrates that common mechanisms are at play in many different diseases because they have a similar context, their vasculature.

This all-inclusive reference book is a must-have tool for researchers and practicing clinicians in the areas of vascular biology, microvasculature, cardiology, and infectious disease.

Covers a wide spectrum of organisms and provides analysis of pathogens and current therapeutic strategies in the context of their vasculature
Provides detailed perspectives on key components contributing to vascular pathogens from leaders in the field
Interfaces between both vascular biology and microbiology by encompassing information on how pathogens affect both macro and microvasculature
Includes coverage of the clinical aspects of sepsis and current therapeutic strategies and anti-sepsis drugs

Produktinformation

Utgivningsdatum2015-10-27
Mått216 x 276 x undefined mm
Vikt930 g
FormatInbunden
SpråkEngelska
Antal sidor252
FörlagElsevier Science
ISBN9780128010785

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Hjärt- och kärlsjukdomar inom Medicin

Dr. Gavins is a pharmacologist whose research interest focuses on developing anti-inflammatory strategies that promote resolution of inflammation following ischemia reperfusion injury (I/RI) in cardiovascular and cerebrovascular diseases. She is specifically interested in the role of the microvasculature as a dynamic-interface between circulating blood- and immune-cells, lymphatics and tissue. Her group studies how circulating cells communicate, adhere and migrate across endothelial borders, along with investigating how circulating and resident cells can render systemic inflammatory responses and alter local inflammatory and thrombotic states. More recently Dr. Gavins has expanded her research to also cover microvascular dysfunction in the setting of organ transplantation, as evidenced by enhanced solute barrier function failure, neutrophil recruitment and endothelial damage. Dr. Stokes major area of research is the inflammatory impact of cytomegalovirus on the microvasculature. Her diverse research team is comprised of post-doctoral scientists and students, with an international reputation. Their research crosses the boundaries between Integrative Physiology and Pharmacology and uses multidisciplinary approaches to advance understanding of the vascular physiology and pathophysiology of inflammatory and related disorders, at the molecular, cellular, tissue and whole organism levels. In particular she and her team focus on the microcirculation, studying leukocyte trafficking and endothelial dysfunction in both the brain and the periphery.

Chapter 1: OverviewChapter 2: SepsisChapter 3: Neutrophil Mediated Vascular Host DefenseChapter 4: Platelet-Bacteria CrosstalkChapter 5: Mechanisms of bacterial interaction with cells of the blood-cerebrospinal fluid barrierChapter 6: Vascular Responses to Chlamydia Pneumoniae InfectionChapter 7: Bartonella Species and Vascular PathologyChapter 8: Periodontal Innate Immune Mechanisms Relevant to Atherosclerosis Chapter 9: H. PyloriChapter 10: Vascular Responses to Pathogens: RickettsiaChapter 11: Herpes VirusesChapter 12: HIV/AntiretroviralsChapter 13: Viral Myocarditis and Dilated Cardiomyopathy: Mechanisms of Cardiac Injury, Inflammation and FibrosisChapter 14: Viruses responsible for Hemorrhagic feversChapter 15: Trypanosoma cruzi and Chagas disease: Innate immunity, ROS, and Cardiovascular SystemChapter 16: Endothelial cells as Targets of the intravascular parasitic disease SchistosomiasisChapter 17: Vascular responses in Human Lymphatic FilariasisChapter 18: The Treatment of Sepsis: From Failed Therapies to New Possibilities