Vascular Mechanobiology in Physiology and Disease

Prof. Markus Hecker is Managing Director of the Institute of Physiology and Pathophysiology, Heidelberg University, Germany.Prof. Dirk Jan Duncker, PhD, MD is an established PI in the field of cardiovascular research and heart failure and head of the department of experimental cardiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands.

• Preface.- Hemodynamics and vascular remodeling.- The biomechanics of venous remodeling.- New kids on the block: the emerging role of YAP/TAZ in vascular cell mechano-transduction.- GPCRs und flow and pressure.- Biomechanics in small artery remodeling.- Contributions of wall stretch and shear stress to vascular regulation: Molecular mechanisms of homeostasis and expansion.- Mechanobiology of lymphatic vessels.- Hemodynamic control of endothelial cell fates in development.- Mechanical regulation of epigenetic modifications in vascular biology and pathobiology.- Mechanosensing and mechanotransduction in pulmonary hypertension.- Mechanobiology of arterial hypertension.- Mechanobiology of atherosclerosis.- Exploitation of vascular mechanobiology for cardiovascular therapy.