This book constitutes the refereed post-conference proceedings of the 6th International Conference on Variable Neighborhood Search, ICVNS 2018, held in Sithonia, Greece, in October 2018.ICVNS 2018 received 49 submissions of which 23 full papers were carefully reviewed and selected.VNS is a metaheuristic based on systematic changes in the neighborhood structure within a search for solving optimization problems and related tasks. The main goal of ICVNS 2018 was to provide a stimulating environment in which researchers coming from various scientific fields could share and discuss their knowledge, expertise, and ideas related to the VNS metaheuristic and its applications.