Vaccine Adjuvants

Inbunden, Engelska, 2005

AvCharles J. Hackett,Donald A. Harn Jr,Charles J Hackett,Donald A Harn Jr

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Modern vaccines are increasingly reliant upon administration with additional substances, termed adjuvants, in order to stimulate effective immune responses. The major biological activity of adjuvant is to mimic infections, binding to specific cellular receptors that recognize components of microbial invaders. This reference brings together new information and perspectives on vaccine adjuvants in a unified synthesis based upon immunological principles. It serves as an essential hand-book that provides continuity and clarity of preentation to a diverse audience of immunologists, vaccinologists, pharmacologists and infectious disease physicians.

Produktinformation

Utgivningsdatum2005-12-01
Mått155 x 235 x 27 mm
Vikt616 g
FormatInbunden
SpråkEngelska
SerieInfectious Disease
Antal sidor284
Upplaga2006
FörlagHumana Press Inc.
ISBN9780896038929

Tillhör följande kategorier

Onkologi inom Medicin
Infektionssjukdomar och smittsamma sjukdomar inom Medicin
Farmakologi inom Medicin

Microbial Pathogenesis and the Discovery of Toll-Like Receptor Function.- Dendritic Cells.- Achieving Transcriptional Specificity in NF-?B-Dependent Inflammatory Gene Expression.- Adjuvants and the Initiation of T-Cell Responses.- Mechanism for Recognition of CpG DNA.- CpG ODN As a Th1 Immune Enhancer for Prophylactic and Therapeutic Vaccines.- Modified Bacterial Toxins.- Glycosylphosphatidylinositol Anchors As Natural Immunological Adjuvants Derived From Protozoan Parasites.- The Immunomodulatory Glycan LNFPIII/Lewis X Functions As a Potent Adjuvant for Protein Antigens.- Immune and Antiviral Effects of the Synthetic Immunomodulator Murabutide.- Effects of QS-21 on Innate and Adaptive Immune Responses.- Monophosphoryl Lipid A and Synthetic Lipid A Mimetics As TLR4-Based Adjuvants and Immunomodulators.- Microparticles and DNA Vaccines.

From the reviews: "This book describes in detail major advances in vaccine adjuvant discovery, design, development, and use. ... fills a void in our knowledge of vaccine adjuvants, providing one authoritative text source for the latest information on this topic. The book meets the authors' objectives superbly. ... it could serve as a reference for students, residents, and practitioners, particularly in the fields of infectious diseases and immunology. ... It will serve as a valuable reference for those interested in this field." (Archana NMI Chatterjee, Doody's Review Service, July, 2006)