Del 50 i serien Wiley Series on Mass Spectrometry

Uremic Toxins

Inbunden, Engelska, 2012

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Reviews all the latest basic and clinical research findingsWith contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices.Uremic Toxins is divided into three sections: Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxinsSection Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEsSection Three, Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbentAll chapters are based on the authors' thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field.Reviewing all the latest basic and clinical research findings, Uremic Toxins will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.

Produktinformation

Utgivningsdatum2012-10-16
Mått163 x 244 x 25 mm
Vikt680 g
FormatInbunden
SpråkEngelska
SerieWiley Series on Mass Spectrometry
Antal sidor400
FörlagJohn Wiley & Sons Inc
ISBN9781118135136

Tillhör följande kategorier

Analytisk kemi inom Naturvetenskap och teknik
Biologi inom Naturvetenskap och teknik
Biokemi inom Naturvetenskap och teknik

TOSHIMITSU NIWA, MD, PhD, is Professor in the Department of Advanced Medicine for Uremia at the Nagoya University Graduate School of Medicine. President of the Japanese Society for Biomedical Mass Spectrometry, Dr. Niwa has received many honors for his research, including the Kimoto Prize of the Japanese Society for Dialysis Therapy and the International Society of Uremia Research and Toxicity Award. He has published more than 300 articles in peer-reviewed journals.

PREFACE ixCONTRIBUTORS xiSECTION 1: UREMIC TOXINS 11. Uremic Toxins: An Integrated Overview of Definition and Classification 3Richard J. Glassock and Shaul G. Massry2. Classification and a List of Uremic Toxins 13Nathalie Neirynck, Rita De Smet, Eva Schepers, Raymond Vanholder, and Griet Glorieux3. Analysis of Uremic Toxins with Mass Spectrometry 35Toshimitsu NiwaSECTION 2: SELECTED UREMIC TOXINS 514. Indoxyl Sulfate 53Toshimitsu Niwa5. p-Cresyl Sulfate 77Anneleen Pletinck, Raymond Vanholder, and Griet Glorieux6. 3-Carboxy-4-methyl-5-propyl-2-furanpropionic Acid 87Toshimitsu Niwa7. Phenylacetic Acid 99Anna Schulz and Joachim Jankowski8. Homocysteine and Hydrogen Sulfide, Two Opposing Aspects in the Pathobiology of Sulfur Compounds in Chronic Renal Failure 109Alessandra F. Perna and Diego Ingrosso9. Guanidino Compounds 125Sunny Eloot, Griet Glorieux, Peter Paul De Deyn, and Raymond Vanholder10. Asymmetric Dimethylarginine 143Vladimýr Teplan and Jaroslav Racek11. Nicotinamide Metabolites 163Boleslaw Rutkowski and Przemyslaw Rutkowski12. Dicarbonyls (Glyoxal, Methylglyoxal, and 3-Deoxyglucosone) 177Naila Rabbani and Paul J. Thornalley13. Glucose Degradation Products in Peritoneal Dialysis 193Monika Pischetsrieder and Sabrina Gensberger14. Dinucleoside Polyphosphates 209Joachim Jankowski and Vera Jankowski15. Parathyroid Hormone 227Shaul G. Massry and Miroslaw Smogorzewski16. b2-Microglobulin 249Suguru Yamamoto, Junichiro James Kazama, Hiroki Maruyama, Ichiei Narita, and Fumitake Gejyo17. Cytokines 259Bj€orn Anderstam, Bengt Lindholm, and Peter Stenvinkel18. Free Immunoglobulin Light Chains 279Gerald Cohen and Walter H. H€orl19. Advanced Glycation Endproducts (AGEs) 293Naila Rabbani and Paul J. Thornalley20. Oxidized Albumin 305Maurizio Bruschi, Giovanni Candiano, Laura Santucci, and Gian Marco GhiggeriSECTION 3: THERAPEUTIC REMOVAL OF UREMIC TOXINS 31521. Therapeutic Removal of Uremic Toxins by Hemodialysis 317Tammy L. Sirich, Pavel Aronov, and Timothy W. Meyer22. Therapeutic Removal of Uremic Toxins by Peritoneal Dialysis 331Malgorzata Debowska, Elvia Garcýa-Lopez, Jacek Waniewski, and Bengt Lindholm23. Therapeutic Removal of Uremic Toxins by Oral Sorbent 359Toshimitsu NiwaINDEX 373