Uptake and Trafficking of Protein Toxins

Inbunden, Engelska, 2017

2 199 kr

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This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake.

Produktinformation

Utgivningsdatum2017-12-19
Mått155 x 235 x 20 mm
Vikt565 g
FormatInbunden
SpråkEngelska
SerieCurrent Topics in Microbiology and Immunology
Antal sidor256
Upplaga17001
FörlagSpringer International Publishing AG
ISBN9783319588919

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Two feet on the membrane: uptake of clostridial neurotoxins.- Receptors and binding structures for Clostridium difficile Toxins A and B.- Cell entry of C3 exoenzyme from Clostridium botulinum.- Receptor-binding and up-take of binary actin-ADP-ribosylating toxins.- Clostridial Binary Toxins: Basic Understandings that Include Cell-Surface Binding and an Internal “Coup de Grace”.- Host cell chaperones Hsp70/Hsp90 and peptidyl-prolyl cis/trans isomerases are required for the membrane translocation of bacterial ADP-ribosylating toxins.- Multivalent Inhibitors of Channel-Forming Bacterial Toxins.- Toxin Transport by A-B Type of Toxins in Eukaryotic Target Cells and its inhibition by Positively Charged Heterocyclic Molecules.