Understanding Nicotine and Tobacco Addiction

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

• Symposium on Understanding nicotine and tobacco addiction, held at the Novartis Foundation, London, 17–19 May 2005Editors: Gregory Bock (Organizer) and Jamie GoodeThis symposium is based on a proposal made by Robert West and Gino van HeekeWilliam A. Corrigall Chair’s introduction 1Richard Peto and Richard Doll The hazards of smoking and the benefits of stopping 3Discussion 15Ian Stolerman Animal models for nicotine dependence 17Discussion 28Robert West Defining and assessing nicotine dependence in humans 36Discussion 52General discussion I 59Uwe Maskos, Sylvie Granon, Philippe Faure and Jean-Pierre Changeux Nicotinic acetylcholine receptor functions in the CNS investigated with a novel method of stereotaxic gene re-expression in knockout mice 64Discussion 79Marina R. Picciotto Nicotine-mediated activation of signal transduction pathways 83Discussion 90David Balfour Complementary roles for the accumbal shell and core in nicotine dependence 96Discussion 105Christian Heidbreder The dopamine D3 system: new opportunities for dopamine-based reward 116Discussion 123Athina Markou Pathways and systems involved in nicotine dependence 132Discussion 145Arthur L. Brody Localizing tobacco dependence pathways with functional brain imaging 153Discussion 166Caryn Lerman Pharmacogenetic approach to nicotine dependence treatment 171Discussion 178Robert Walton Pharmacogenomics and smoking cessation 184Discussion 194General discussion II Power in studies 197Receptor desensitization 199Peter Hajek What limits the efficacy of current nicotine replacement therapies? 204Discussion 213Saul Shiffman, Stuart Ferguson and Deborah Scharf Exploring behavioural mechanisms of nicotine replacement therapy for smoking cessation 219Discussion 231Rachel F. Tyndale and Edward M. Sellers Modifying the metabolism of nicotine as a therapeutic strategy 235Discussion 244William A. Corrigall Challenges in discovery and development of pharmacotherapies for tobacco addiction 249Discussion 259Final discussion Nicotine comorbidity 262Animal models 264Index of contributors 266Subject index 268

"…an excellent resource for individuals interested in this area." (Doody's Health Services) "…thinking of all the clients…who smoke… Do we not owe it to our clients to save them from this Killer?" (Journal of Mental Health and Psychiatric Nursing, September 2007)