Understanding DNA

Chris Calladine is Professor of Structural Mechanics at the University of Cambridge. In addition to researching aspects of structural engineering, he has applied the methods of structural mechanics to the study of flagella and DNA. Horace Drew solved several of the first DNA crystal X-ray structures with Richard Dickerson at Caltech, and subsequently spent five years researching DNA and chromosome structures with Aaron Klug at the MRC Laboratory of Molecular Biology in Cambridge, UK He now lives in Australia and is a Principle Research Scientist at the CSIRO Division of Biomolecular Engineering in Sydney. Ben Luisi works in the Department of Biochemistry at the University of Cambridge, where he has an appointment as professor of structural biology. He and his colleagues study the structure and mechanism of efflux pumps and the riboregulatory machinery that help to control the expression of the pumps and other complex systems in bacteria.

• An Introduction to Molecular Biology for Non-ScientistsWhy a Helix?Different Kinds of Double HelixTwisting and CurvingCurving in Three DimensionsDNA SupercoilingThe Assembly of DNA intor ChromosomesSpecific DNA-Protein InteractionsMethods Used to Study the Structure of DNADNA in Disease, Diagnostics and MedicineCytosine Methylation and DNA EpigeneticsAppendix1: Notes on the Derivation of Some Technical Terms2: The Chemical Theory of Base-stacking Interactions in DNA3: How to modify Gene Expression by means of Anti-sense Oligonucleotides, Ribozymes or si-RNA

Praise for previous editions:"Stylish...beautifully crafted, with a logical step-by-step approach to the subject. A book from which the advanced undergraduate will benefit and which will also generate a refreshing perspective for experts" --NATURE"Understanding DNA is a great book that will surely prove to be a valuable teaching tool." --THE BIOCHEMIST"A systematic and comprehensive analysis of the structure of DNA from a wonderfully fresh perspective." --TRENDS IN GENETICS