This volume explores the study of the brain ultrastructure using various methodological approaches from different perspectives. The chapters in this book cover topics such as biological sample preparation, transmission and scanning electron microscopy imaging, and cutting-edge qualitative and quantitative analysis. The chapters provide essential considerations and protocols for the study of animal models, human cellular models, and human post-mortem brain samples across contexts of health and disease. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.Comprehensive and thorough, Ultrastructural Neuroscience Methods is a key resource for biomedical, translational, and clinical researchers interested in delving into the mysteries of the brain at a nanoscale resolution.