Tumor-Induced Immune Suppression

Mechanisms and Therapeutic Reversal

Häftad, Engelska, 2010

AvDmitry I. Gabrilovich,Arthur Andrew Hurwitz

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There is now a pressing need to discuss the already described and newly emerging mechanisms to see how they can be put together in more or less cohesive structure and how they can help to improve immune response to tumors. This monograph will, for the first time, present a comprehensive overview of different mechanisms of immune dysfunction in cancer as well as therapeutic approaches to their correction. It will discuss a number of new mechanisms that have never been discussed in a monograph before: T-cell inhibitory molecules, regulatory tolerogenic DCs, and signaling pathways in antigen-presenting cells involved in T-cell tolerance.

Produktinformation

Utgivningsdatum2010-10-29
Mått155 x 235 x undefined mm
Vikt476 g
FormatHäftad
SpråkEngelska
Antal sidor302
Upplaga2008
FörlagSpringer-Verlag New York Inc.
ISBN9781441924001

Tillhör följande kategorier

Onkologi inom Medicin
Cellbiologi inom Naturvetenskap och teknik
Patologi inom Medicin

Immune-Suppressive Mechanisms and Cancer: Understanding the Implications, Paradoxes, and Burning Questions.- Mechanisms of Tumor-Associated T-Cell Tolerance.- Contribution of B7-H1/PD-1 Co-inhibitory Pathway to T-Cell Dysfunction in Cancer.- Regulatory T Cells in Cancer.- Cancer-Induced Signaling Defects in Antitumor T Cells.- Immunobiology of Dendritic Cells in Cancer.- Macrophages and Tumor Development.- Myeloid-Derived Suppressor Cells in Cancer.- Signaling Pathways in Antigen-Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance.- Arginine Availability Regulates T-Cell Function in Cancer.- Protein–Glycan Interactions in the Regulation of Immune Cell Function in Cancer: Lessons from the Study of Galectins-1 and -3.- Role of Reactive Oxygen Species in T-Cell Defects in Cancer.- Tumor Stroma and the Antitumor Immune Response.

From the reviews: "The overall goal of this book is to describe what is currently known about the ways tumors circumvent destruction by the host's immune system. ... The book is targeted at researchers -- immunologists in general and, more specifically, tumor immunologists. It also provides a good source of information for graduate students and postdoctoral fellows. The editors of the book and the authors of the chapters are authorities in the areas they discuss. ... a useful addition to the field." (Marion C. Cohen, Doody's Review Service, August, 2008)